Bone marrow mesenchymal stromal cells (BMSCs), identified as pericytes comprising the
hematopoietic niche, are a group of heterogeneous cells composed of multipotent stem …

The meninges are the fibrous covering of the central nervous system (CNS) which contain
vastly heterogeneous cell types within its three layers (dura, arachnoid, and pia). The dural …

Cranial neural crest cells are an evolutionary innovation of vertebrates for craniofacial
development and function, yet the mechanisms that govern the cell fate decisions of …

Craniosynostosis is a group of disorders of premature calvarial suture fusion. The identity of
the calvarial stem cells (CSCs) that produce fusion-driving osteoblasts in craniosynostosis …

Background Recent investigations of the meninges have highlighted the importance of the
dura layer in central nervous system immune surveillance beyond a purely structural role …

Craniosynostosis is a major congenital craniofacial disorder characterized by the premature
fusion of cranial suture (s). Patients with severe craniosynostosis often have impairments in …

Lizards cannot naturally regenerate limbs but are the closest known relatives of mammals
capable of epimorphic tail regrowth. However, the mechanisms regulating lizard blastema …

In newborn humans, and up to approximately 2 y of age, calvarial bone defects can naturally
regenerate. This remarkable regeneration potential is also found in newborn mice and is …

The craniofacial bones provide structural support for the skull and accommodate the
vulnerable brain tissue with a protective cavity. The bone tissue undergoes constant …

The genetic basis of human facial variation and craniofacial birth defects remains poorly
understood. Distant-acting transcriptional enhancers control the fine-tuned spatiotemporal …