Triglyceride molecules represent the major form of storage and transport of fatty acids within
cells and in the plasma. The liver is the central organ for fatty acid metabolism. Fatty acids …

The endoplasmic reticulum (ER) is a complex and dynamic organelle that regulates many
cellular pathways, including protein synthesis, protein quality control, and lipid synthesis …

Abstract γδ T cells are situated at barrier sites and guard the body from infection and
damage. However, little is known about their roles outside of host defense in nonbarrier …

Farnesoid X receptor (FXR) is a promising target for nonalcoholic steatohepatitis (NASH)
and fibrosis. Although various FXR agonists have shown anti-fibrotic effects in diverse …

Summary Uncoupling protein 1 (UCP1) is a major regulator of brown and beige adipocyte
energy expenditure and metabolic homeostasis. However, the widely employed UCP1 loss …

The cellular uptake of free fatty acids (FFA) is followed by esterification to coenzyme A
(CoA), generating fatty acyl-CoAs that are substrates for oxidation or incorporation into …

The energy expending and glucose sink properties of brown adipose tissue (BAT) make it
an attractive target for new obesity and diabetes treatments. Despite decades of research …

The rise in obesity over the last several decades has reached pandemic proportions. Brown
adipose tissue (BAT) is a thermogenic organ that is involved in energy expenditure and …

Activating nonshivering thermogenesis in brown adipose tissue (BAT) is a promising
strategy to prevent obesity. This study investigated whether quercetin supplementation …

Recent studies suggest that a key mechanism whereby the gut microbiome influences
energy balance and glucose homeostasis is through the recruitment of brown and beige …