Coagulation proteased-induced extracellular vesicles: Their potential effects on coagulation and inflammation
K Das, LVM Rao - Journal of Thrombosis and Haemostasis, 2024 - Elsevier
Coagulation proteases, in addition to playing an essential role in blood coagulation, often
influence diverse cellular functions by inducing specific signaling pathways via the activation …
influence diverse cellular functions by inducing specific signaling pathways via the activation …
Factor XI as a therapeutic target in neuroinflammatory disease
This review emphasizes the role of FXII and FXI in regulating barrier function and the
immune response in neuroinflammation. These new findings broaden the potential for …
immune response in neuroinflammation. These new findings broaden the potential for …
An orthosteric/allosteric bivalent peptide agonist comprising covalently linked protease-activated receptor-derived peptides mimics in vitro and in vivo activities of …
Abstract Background Activated protein C (APC) has anticoagulant and cytoprotective cell-
signaling activities, which often require protease-activated receptor (PAR) 1 and PAR3 and …
signaling activities, which often require protease-activated receptor (PAR) 1 and PAR3 and …
Mimicking activated protein C-progress by PARtnering peptides
H Fleming, RJS Preston - Journal of Thrombosis and Haemostasis, 2024 - jthjournal.org
In addition to their role in blood coagulation, plasma proteases can shape cell behavior via
receptor-mediated signaling [1]. Although the range of receptors and cell types susceptible …
receptor-mediated signaling [1]. Although the range of receptors and cell types susceptible …
No Causal Relationship Between Coagulation Factors and Sepsis-Related Risks: A Mendelian Randomization Study
J Lei, J Qi, J Zhai, Y Zhang, C Sun - 2024 - researchsquare.com
Background Sepsis is a life-threatening organ dysfunction caused by a dysregulated host
response to infection. Among the critical hallmarks of sepsis progression is the abnormal …
response to infection. Among the critical hallmarks of sepsis progression is the abnormal …