Ellagic acid prevents kidney injury and oxidative damage via regulation of Nrf-2/NF-κB signaling in carbon tetrachloride induced rats

A Aslan, O Gok, S Beyaz, CA Ağca, O Erman… - Molecular biology …, 2020 - Springer
Phytochemicals, bioactive food compounds, found in plants have been described as
protective agents against renal injury. This work was planned to evaluate the effects of EA …

[HTML][HTML] The effects of casticin and myricetin on liver damage induced by methotrexate in rats

FN Eki̇nci̇-Akdemi̇r, S Yildirim… - Iranian journal of …, 2018 - ncbi.nlm.nih.gov
Objective (s): In this study, we evaluated the therapeutic effects of casticin and myricetin on
liver damage induced by methotrexate in rats. Materials and Methods: Thirty-six male rats …

[HTML][HTML] Gallic acid protects against bisphenol A-induced alterations in the cardio-renal system of Wistar rats through the antioxidant defense mechanism

OE Ola-Davies, SG Olukole - Biomedicine & Pharmacotherapy, 2018 - Elsevier
Bisphenol A (BPA) is a small molecular weight endocrine disrupting chemical (EDC) that is
used in the production of plastics with deleterious effects on various body systems while …

Zein/phospholipid composite nanoparticles for successful delivery of gallic acid into ahscs: Influence of size, surface charge, and vitamin a coupling

SAA Radwan, WH El-Maadawy, C Yousry… - International journal …, 2020 - Taylor & Francis
Purpose Zein/phospholipid composite nanoparticles (CNPs) were developed as a delivery
platform for gallic acid (GA), a polyphenolic compound with reported preclinical antifibrotic …

Microencapsulation of gallic acid by spray drying with aloe vera mucilage (aloe barbadensis miller) as wall material

L Medina-Torres, DM Núñez-Ramírez… - Industrial Crops and …, 2019 - Elsevier
Abstract Mucilage of Aloe vera (Aloe barbadensis Miller) is an alternative agent for
microencapsulation by spray drying of labile bioactives, such as gallic acid. The …

L‐carnitine reverses methotrexate‐induced nephrotoxicity in experimental rat model: Insight on SIRT1/PGC‐1α/Nrf2/HO‐1 axis

SM Radwan, M Alqulaly, MY Elsaeed… - Journal of Applied …, 2023 - Wiley Online Library
Methotrexate (MTX) is a chemotherapeutic agent used for treating several types of cancer as
well as psoriasis and rheumatoid arthritis, but its use is limited due to its nephrotoxicity. The …

Gallic acid ameliorates sodium arsenite-induced renal and hepatic toxicity in rats

B Gholamine, G Houshmand… - Drug and chemical …, 2021 - Taylor & Francis
Chronic exposure to toxic inorganic arsenic results in the adverse health effects including
skin lesions, cardiovascular diseases, diabetes, neurological disorders, and liver and kidney …

Protective effect of pycnogenol against methotrexate-induced hepatic, renal, and cardiac toxicity: An in vivo study

F Al-Abkal, BA Abdel-Wahab, HFA El-Kareem… - Pharmaceuticals, 2022 - mdpi.com
Methotrexate (MTX) is one of the most commonly used chemotherapies for various types of
cancer, including leukemia, breast cancer, hepatocarcinoma, and gastric cancers. However …

Involvement of Nrf2/HO-1 antioxidant signaling and NF-κB inflammatory response in the potential protective effects of vincamine against methotrexate-induced …

YM Shalaby, ET Menze, SS Azab, AS Awad - Archives of toxicology, 2019 - Springer
Methotrexate (MTX) is a cytotoxic chemotherapeutic agent widely used in the treatment of
cancer and autoimmune diseases like rheumatoid arthritis. However, its use has been …

Protective effects of natural products against drug-induced nephrotoxicity: A review in recent years

C Gao, C Liu, Y Chen, Q Wang, Z Hao - Food and Chemical Toxicology, 2021 - Elsevier
Drug-induced nephrotoxicity (DIN) is a major cause of kidney damage and is associated
with high mortality and morbidity, which limits the clinical use of certain therapeutic or …