Multidrug transporters constitute major mechanisms of MDR in human cancers. The ABCB1
(MDR1) gene encodes a well-characterized transmembrane transporter, termed P …

Cancer is also an epigenetic disease. The main epigenetic modification in humans is DNA
methylation. Transformed cells undergo a dramatic change in their DNA methylation …

Overexpression of the human multidrug resistance gene 1 (MDR1) is a negative prognostic
factor in leukemia. Despite intense efforts to characterize the gene at the molecular level …

The detection of 5′-methylcytosine by the bisulphate-mediated genomic sequencing
method has considerably aided study of the role of methylation in areas such as X …

DNA methylation strongly affects chromatin structure and the regulation of gene expression.
For many years, bisulfite sequencing PCR (BSP) has served as the “gold standard” for …

ATP-binding cassette (ABC) transporters play a crucial role in multidrug resistance (MDR) of
cancers. They function as efflux pumps, resulting in limited effectiveness or even failure of …

In recent years, the different classes of drugs and regimens used clinically have provided an
improvement in tumour management. However, treatment is often palliative for the majority …

Background The development of resistance to cytotoxic chemotherapy continues to be a
major obstacle for successful anticancer therapy. It has been shown that cells exposed to …

BACKGROUND: Secondary acute myeloid leukemia (AML) from an antecedent
myelodysplastic syndrome (MDS)/myeloproliferative neoplasm is associated with a poor …

Resistance to the cytotoxic actions of antineoplastic drugs, whether intrinsic or acquired,
remains a barrier to the establishment of curative chemotherapy regimens for advanced …