Osteoarthritis (OA) has long been viewed as a degenerative disease of cartilage, but
accumulating evidence indicates that inflammation has a critical role in its pathogenesis …

In diarthrodial joints, the articular cartilage, calcified cartilage, and subchondral cortical and
trabecular bone form a biocomposite—referred to as the osteochondral unit—that is …

Osteoarthritis (OA) represents a final and common pathway for all major traumatic insults to
synovial joints. OA is the most common form of degenerative joint disease and a major …

Introduction: Osteoarthritis (OA) is a leading cause of pain and disability among adults with a
current prevalence of around 15% and a predicted prevalence of 35% in 2030 for …

Senescent cells (SnCs) are associated with age-related pathologies. Osteoarthritis is a
chronic disease characterized by pain, loss of cartilage, and joint inflammation, and its …

Current cell-based repair strategies have proven unsuccessful for treating cartilage defects
and osteoarthritic lesions, consequently advances in innovative therapeutics are required …

Objectives This study aimed to investigate the roles of adipose mesenchymal stem cell
(AMSC)-derived extracellular vesicles (EVs) binding with chitosan oligosaccharides (COS) …

Purpose The aim of this “Year in Review” article is to summarize and discuss the
implications of biochemical marker related articles published between the Osteoarthritis …

Highlights•Different OA etiologies present a challenge for developing a single targeted
therapy.•Common mechanisms occur in inflammatory, mechanical, and oxidative stress in …

OA is a multifaceted and heterogeneous syndrome that may be amenable to tailored
treatment. There has been an increasing focus within the OA research community on the …