Rheumatoid arthritis (RA) is characterized by inflammation and destruction of bone and
cartilage in affected joints. Autoimmune responses lead to increased osteoclastic bone …

Postmenopausal osteoporosis is a systemic disease characterized by the loss of bone mass
and increased bone fracture risk largely resulting from significantly reduced levels of the …

Periodontitis and osteoporosis are prevalent inflammation‐associated skeletal disorders that
pose significant public health challenges to our aging population. Both periodontitis and …

Rheumatoid arthritis (RA) is an autoimmune disease that involves multiple joints bilaterally.
It is characterized by an inflammation of the tendon (tenosynovitis) resulting in both cartilage …

Musculoskeletal trauma leading to broken and damaged bones and soft tissues can be a life-
threating event. Modern orthopaedic trauma surgery, combined with innovation in medical …

Increased osteoclast (OC) differentiation and activity is the critical event that results in bone
loss and joint destruction in common pathological bone conditions, such as osteoporosis …

Osteoarthritis (OA) is a degenerative joint disease in the elderly. Although OA has been
considered as primarily a disease of the articular cartilage, the participation of subchondral …

Psoriatic arthritis (PsA) is part of a group of closely related clinical phenotypes ('psoriatic
disease') that is defined by shared molecular pathogenesis resulting in excessive …

The biology of bone healing is a rapidly developing science. Advances in transgenic and
gene‐targeted mice have enabled tissue and cell‐specific investigations of skeletal …

Bone remodeling is tightly controlled by osteoclast-mediated bone resorption and osteoblast-
mediated bone formation. Fine tuning of the osteoclast–osteoblast balance results in strict …