Absorption, metabolism, and functions of hyaluronic acid and its therapeutic prospects in combination with microorganisms: A review

X Zheng, B Wang, X Tang, B Mao, Q Zhang… - Carbohydrate …, 2023 - Elsevier
Hyaluronic acid (HA) is key to the stability of the internal environment of tissues. HA content
in tissues gradually decreases with age, causing age-related health problems. Exogenous …

Current advances in the biosynthesis of hyaluronic acid with variable molecular weights

Y Qiu, Y Ma, Y Huang, S Li, H Xu, E Su - Carbohydrate Polymers, 2021 - Elsevier
Hyaluronic acid (HA) is a naturally formed acidic mucopolysaccharide, with excellent
moisturising properties and used widely in the medicine, cosmetics, and food industries. The …

Structure, substrate recognition and initiation of hyaluronan synthase

FP Maloney, J Kuklewicz, RA Corey, Y Bi, R Ho… - Nature, 2022 - nature.com
Hyaluronan is an acidic heteropolysaccharide comprising alternating N-acetylglucosamine
and glucuronic acid sugars that is ubiquitously expressed in the vertebrate extracellular …

Engineering Corynebacterium glutamicum for high-titer biosynthesis of hyaluronic acid

F Cheng, H Yu, G Stephanopoulos - Metabolic engineering, 2019 - Elsevier
Hyaluronic acid (HA) is a member of the glycosaminoglycan family and has been widely
used in the clinical, medical, cosmetic and food industries. In this study, we constructed a …

Comprehensive review on biosynthesis of hyaluronic acid with different molecular weights and its biomedical applications

F Jabbari, V Babaeipour, S Saharkhiz - International Journal of Biological …, 2023 - Elsevier
Hyaluronic acid (HA), an anionic and nonsulfated glycosaminoglycan, is the main structural
component of various tissues and plays an important role in various biological processes …

Fluorinated-functionalized hyaluronic acid nanoparticles for enhanced photodynamic therapy of ocular choroidal melanoma by ameliorating hypoxia

J Li, Y Xue, J Tian, Z Liu, A Zhuang, P Gu, H Zhou… - Carbohydrate …, 2020 - Elsevier
Photodynamic therapy (PDT) is a method for killing cancer cells by employing reactive
singlet oxygen (1 O 2). However, the inherent hypoxia and oxygen consumption in tumors …

[HTML][HTML] Biosynthesis of hyaluronic acid polymer: dissecting the role of sub structural elements of hyaluronan synthase

G Agarwal, K KV, SB Prasad, A Bhaduri… - Scientific reports, 2019 - nature.com
Hyaluronic acid (HA) based biomaterials have several biomedical applications. HA
biosynthesis is catalysed by hyaluronan synthase (HAS). The unavailability of 3-D structure …

Controlled processivity in glycosyltransferases: A way to expand the enzymatic toolbox

C Guidi, X Biarnés, A Planas, M De Mey - Biotechnology Advances, 2023 - Elsevier
Glycosyltransferases (GT) catalyse the biosynthesis of complex carbohydrates which are the
most abundant group of molecules in nature. They are involved in several key mechanisms …

Production of different molecular weight glycosaminoglycans with microbial cell factories

D Wang, L Hu, R Xu, W Zhang, H Xiong, Y Wang… - Enzyme and Microbial …, 2023 - Elsevier
Glycosaminoglycans (GAGs) are naturally occurring acidic polysaccharides with wide
applications in pharmaceuticals, cosmetics, and health foods. The diverse biological …

Computational Study of Complex Formation between Hyaluronan Polymers and Polyarginine Peptides at Various Ratios

N Kulik, B Minofar, A Jugl, M Pekař - Langmuir, 2023 - ACS Publications
Hyaluronic acid, a naturally occurring carbohydrate biopolymer in human tissues, finds wide
application in cosmetics, medicine, and material science. Its anionic properties play a crucial …