[HTML][HTML] Monitoring the 5′ UTR landscape reveals isoform switches to drive translational efficiencies in cancer

R Weber, U Ghoshdastider, D Spies, C Duré… - Oncogene, 2023 - nature.com
Transcriptional and translational control are key determinants of gene expression, however,
to what extent these two processes can be collectively coordinated is still poorly understood …

[HTML][HTML] The progress of multi-omics technologies: determining function in lactic acid bacteria using a systems level approach

ST O'Donnell, RP Ross, C Stanton - Frontiers in microbiology, 2020 - frontiersin.org
Lactic Acid Bacteria (LAB) have long been recognized as having a significant impact
ranging from commercial to health domains. A vast amount of research has been carried out …

[HTML][HTML] Single-molecule long-read sequencing reveals a conserved intact long RNA profile in sperm

YH Sun, A Wang, C Song, G Shankar… - Nature …, 2021 - nature.com
Sperm contributes diverse RNAs to the zygote. While sperm small RNAs have been shown
to impact offspring phenotypes, our knowledge of the sperm transcriptome, especially the …

Long-read sequencing reveals oncogenic mechanism of HPV-human fusion transcripts in cervical cancer

M Liu, Z Han, Y Zhi, Y Ruan, G Cao, G Wang, X Xu… - Translational …, 2023 - Elsevier
Integration of high-risk human papillomavirus (HPV) into the host genome is a crucial event
for the development of cervical cancer, however, the underlying mechanism of HPV …

[HTML][HTML] Systematic assessment of long-read RNA-seq methods for transcript identification and quantification

FJ Pardo-Palacios, D Wang, F Reese, M Diekhans… - Nature …, 2024 - nature.com
Abstract The Long-read RNA-Seq Genome Annotation Assessment Project Consortium was
formed to evaluate the effectiveness of long-read approaches for transcriptome analysis …

Comprehensive isoform-level analysis reveals the contribution of alternative isoforms to venom evolution and repertoire diversity

X Ye, C He, Y Yang, YH Sun, S Xiong… - Genome …, 2023 - genome.cshlp.org
Animal venom systems have emerged as valuable models for investigating how novel
polygenic phenotypes may arise from gene evolution by varying molecular mechanisms …

[HTML][HTML] TAGET: a toolkit for analyzing full-length transcripts from long-read sequencing

Y Xia, Z Jin, C Zhang, L Ouyang, Y Dong, J Li… - Nature …, 2023 - nature.com
Abstract Single-molecule Real-time Isoform Sequencing (Iso-seq) of transcriptomes by
PacBio can generate very long and accurate reads, thus providing an ideal platform for full …

Transposon-mediated horizontal transfer of the host-specific virulence protein ToxA between three fungal wheat pathogens

MC McDonald, AP Taranto, E Hill, B Schwessinger… - MBio, 2019 - Am Soc Microbiol
Most known examples of horizontal gene transfer (HGT) between eukaryotes are ancient.
These events are identified primarily using phylogenetic methods on coding regions alone …

[HTML][HTML] Single-molecule, full-length transcript isoform sequencing reveals disease-associated RNA isoforms in cardiomyocytes

C Zhu, J Wu, H Sun, F Briganti, B Meder, W Wei… - Nature …, 2021 - nature.com
Alternative splicing generates differing RNA isoforms that govern phenotypic complexity of
eukaryotes. Its malfunction underlies many diseases, including cancer and cardiovascular …

Identification of region-specific gene isoforms in the human brain using long-read transcriptome sequencing

M Shimada, Y Omae, A Kakita, R Gabdulkhaev… - Science …, 2024 - science.org
In neurological and neuropsychiatric diseases, different brain regions are affected, and
differences in gene expression patterns could potentially explain this mechanism. However …