[HTML][HTML] Monitoring the 5′ UTR landscape reveals isoform switches to drive translational efficiencies in cancer
R Weber, U Ghoshdastider, D Spies, C Duré… - Oncogene, 2023 - nature.com
Transcriptional and translational control are key determinants of gene expression, however,
to what extent these two processes can be collectively coordinated is still poorly understood …
to what extent these two processes can be collectively coordinated is still poorly understood …
[HTML][HTML] The progress of multi-omics technologies: determining function in lactic acid bacteria using a systems level approach
Lactic Acid Bacteria (LAB) have long been recognized as having a significant impact
ranging from commercial to health domains. A vast amount of research has been carried out …
ranging from commercial to health domains. A vast amount of research has been carried out …
[HTML][HTML] Single-molecule long-read sequencing reveals a conserved intact long RNA profile in sperm
Sperm contributes diverse RNAs to the zygote. While sperm small RNAs have been shown
to impact offspring phenotypes, our knowledge of the sperm transcriptome, especially the …
to impact offspring phenotypes, our knowledge of the sperm transcriptome, especially the …
Long-read sequencing reveals oncogenic mechanism of HPV-human fusion transcripts in cervical cancer
M Liu, Z Han, Y Zhi, Y Ruan, G Cao, G Wang, X Xu… - Translational …, 2023 - Elsevier
Integration of high-risk human papillomavirus (HPV) into the host genome is a crucial event
for the development of cervical cancer, however, the underlying mechanism of HPV …
for the development of cervical cancer, however, the underlying mechanism of HPV …
[HTML][HTML] Systematic assessment of long-read RNA-seq methods for transcript identification and quantification
Abstract The Long-read RNA-Seq Genome Annotation Assessment Project Consortium was
formed to evaluate the effectiveness of long-read approaches for transcriptome analysis …
formed to evaluate the effectiveness of long-read approaches for transcriptome analysis …
Comprehensive isoform-level analysis reveals the contribution of alternative isoforms to venom evolution and repertoire diversity
Animal venom systems have emerged as valuable models for investigating how novel
polygenic phenotypes may arise from gene evolution by varying molecular mechanisms …
polygenic phenotypes may arise from gene evolution by varying molecular mechanisms …
[HTML][HTML] TAGET: a toolkit for analyzing full-length transcripts from long-read sequencing
Abstract Single-molecule Real-time Isoform Sequencing (Iso-seq) of transcriptomes by
PacBio can generate very long and accurate reads, thus providing an ideal platform for full …
PacBio can generate very long and accurate reads, thus providing an ideal platform for full …
Transposon-mediated horizontal transfer of the host-specific virulence protein ToxA between three fungal wheat pathogens
Most known examples of horizontal gene transfer (HGT) between eukaryotes are ancient.
These events are identified primarily using phylogenetic methods on coding regions alone …
These events are identified primarily using phylogenetic methods on coding regions alone …
[HTML][HTML] Single-molecule, full-length transcript isoform sequencing reveals disease-associated RNA isoforms in cardiomyocytes
Alternative splicing generates differing RNA isoforms that govern phenotypic complexity of
eukaryotes. Its malfunction underlies many diseases, including cancer and cardiovascular …
eukaryotes. Its malfunction underlies many diseases, including cancer and cardiovascular …
Identification of region-specific gene isoforms in the human brain using long-read transcriptome sequencing
M Shimada, Y Omae, A Kakita, R Gabdulkhaev… - Science …, 2024 - science.org
In neurological and neuropsychiatric diseases, different brain regions are affected, and
differences in gene expression patterns could potentially explain this mechanism. However …
differences in gene expression patterns could potentially explain this mechanism. However …