The heme oxygenases, which consist of constitutive and inducible isozymes (HO-1, HO-2),
catalyze the rate-limiting step in the metabolic conversion of heme to the bile pigments (ie …

Although oxidants clearly possess the capacity to behave in a random and destructive
fashion, growing evidence suggests that in many instances the production of reactive …

The heme-heme oxygenase system has recently been recognized to possess important
regulatory properties. It is tightly involved in both physiological as well as pathophysiological …

Hemopexin is an acute-phase plasma glycoprotein, produced mainly by the liver and
released into plasma, where it binds heme with high affinity. Other sites of hemopexin …

Heme oxygenase (HO) is an enzyme responsible for the physiological degradation of heme
to produce iron, CO and biliverdin. The released iron is recycled and represents the major …

Every cell has a highly sophisticated system for regulating heme levels, which is particularly
important with regard to turnover. Heme degradation generates CO and while CO has long …

Modulation of endogenous cellular defense mechanisms via the vitagene system represents
an innovative approach to therapeutic intervention in diseases causing chronic tissue …

Reduced expression and/or activity of antioxidant proteins lead to oxidative stress,
accelerated aging and neurodegeneration. However, while excess reactive oxygen species …

Heme oxygenase-1 (HO-1), a cytoprotective enzyme, can be induced in tumors in response
to anti-cancer therapies. We investigated the role of HO-1 in B16 (F10), S91, and Sk-mel188 …

Oxidative damage to retinal pigment epithelial (RPE) has been identified as one of the major
regulatory factors in the pathogenesis of age-related macular degeneration (AMD). Catalpol …