Atherosclerotic coronary artery disease (CAD) comprises a broad spectrum of clinical
entities that include asymptomatic subclinical atherosclerosis and its clinical complications …

Hypercholesterolemia is a strong determinant of mortality and morbidity associated with
cardiovascular diseases and a major contributor to the global disease burden. Mutations in …

Sortilin is a post-Golgi trafficking receptor homologous to the yeast vacuolar protein sorting
receptor 10 (VPS10). The VPS10 motif on sortilin is a 10-bladed β-propeller structure …

Cardiovascular disease is a leading cause of morbidity and mortality in the Western world.
Studies of sortilin's influence on cardiovascular and metabolic diseases goes far beyond the …

Maladaptive inflammatory and immune responses are responsible for intestinal barrier
integrity and function dysregulation. Proline/serine-rich coiled-coil protein 1 (PSRC1) …

The majority of risk loci identified by genome-wide association studies (GWAS) are in non-
coding regions, hampering their functional interpretation. Instead, transcriptome-wide …

The amyloid precursor protein (APP), one key player in Alzheimer's disease (AD), is
extensively processed by different proteases. This leads to the generation of diverging …

Several genome-wide association studies have linked novel loci to a wide range of
cardiovascular phenotypes including low-density lipoprotein (LDL)-cholesterol, early onset …

Genetic variants in the genomic region containing SORT1 (encoding the protein sortilin) are
strongly associated with cholesterol levels and the risk of coronary artery disease (CAD) …

Isolating the causal genes from numerous genetic association signals in genome-wide
association studies (GWASs) of complex phenotypes remains an open and challenging …