Bile acids are a large family of atypical steroids which exert their functions by binding to a
family of ubiquitous cell membrane and nuclear receptors. There are two main bile acid …

Bile acids (BAs) are evolutionally conserved molecules synthesized in the liver from
cholesterol and have been shown to be essential for lipid homeostasis. BAs regulate a …

Gut microbiota dysregulation plays a key role in the pathogenesis of nonalcoholic fatty liver
disease (NAFLD) through its metabolites. Therefore, the restoration of the gut microbiota and …

FXR agonists are used to treat non-alcoholic fatty liver disease (NAFLD), in part because
they reduce hepatic lipids. Here, we show that FXR activation with the FXR agonist …

Liver fibrosis accompanies the progression of chronic liver diseases independent of
etiologies, such as hepatitis viral infection, alcohol consumption, and metabolic-associated …

Nonalcoholic fatty liver disease (NAFLD), a series of liver metabolic disorders manifested by
lipid accumulation within hepatocytes, has become the primary cause of chronic liver …

Abstract Non-Alcoholic Fatty Liver Disease (NAFLD) comprises a wide spectrum of liver
injuries from simple steatosis to steatohepatitis and cirrhosis. Non-Alcoholic Steatohepatitis …

Bile acids (BA) are amphiphilic molecules synthesized in the liver (primary BA) starting from
cholesterol. In the small intestine, BA act as strong detergents for emulsification …

Introduction Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty
liver disease (NAFLD) for which therapy is suboptimal. The farnesoid-X-receptor (FXR) and …

Gut microbiota (GM) dysbiosis and bile acid (BA) metabolism disorder play an important role
in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Probiotics had a beneficial …