Mucosal surfaces are lined by epithelial cells. These cells establish a barrier between
sometimes hostile external environments and the internal milieu. However, mucosae are …

The diversity in the biological response of 4-thiazolidinones has attracted the attention of
many researchers to explore this framework for its potential. It is, therefore, of prime …

Which elements are essential for human life? Here we make an element-by-element journey
through the periodic table and attempt to assess whether elements are essential or not, and …

This review focuses on the role and regulation of mucin glycoproteins (mucins) in airway
health and disease. Mucins are highly glycosylated macromolecules (≥ 50% carbohydrate …

Cl− channels reside both in the plasma membrane and in intracellular organelles. Their
functions range from ion homeostasis to cell volume regulation, transepithelial transport, and …

Multidrug Resistance Proteins (MRPs), together with the cystic fibrosis conductance
regulator (CFTR/ABCC7) and the sulfonylurea receptors (SUR1/ABCC8 and SUR2/ABCC9) …

Secretory diarrhea is the leading cause of infant death in developing countries and a major
cause of morbidity in adults. The cystic fibrosis transmembrane conductance regulator …

Cyclic AMP (cAMP) is a key second messenger in all cells. It is compartmentalized within
cells and its levels are controlled, as a result of spatially discrete signaling cassettes …

Chloride channels represent a relatively under-explored target class for drug discovery as
elucidation of their identity and physiological roles has lagged behind that of many other …

Lipopolysaccharide (LPS) is the principal proinflammatory component of the Gram-negative
bacterial envelope and is recognized by the Toll-like receptor 4 (TLR4)–MD-2 receptor …