The most common cause of cystic fibrosis (CF) is deletion of phenylalanine 508 (ΔF508) in
the CF transmembrane conductance regulator (CFTR) chloride channel. The ΔF508 …

Lactoperoxidase (LPO) is an enzyme with antimicrobial properties present in saliva, milk,
tears, and airway secretions. Although the formation of microbicidal oxidants by LPO has …

Abstract Objectives Chronic infections of Pseudomonas aeruginosa in the lungs of cystic
fibrosis patients are intractable antibiotic targets because of their biofilm mode of growth. We …

Recent evidence suggests that the airway mucus gel layer may be impermeable to the viral
and synthetic gene vectors used in past inhaled gene therapy clinical trials for diseases like …

Cystic fibrosis (CF) is a disease caused by mutations in the cystic fibrosis transmembrane
conductance regulator (CFTR). Initially, Cl-conductance in the sweat duct was discovered to …

In cystic fibrosis, dysregulated neutrophilic inflammation and chronic infection lead to
progressive destruction of the airways. The underlying mechanisms have remained unclear …

Cystic Fibrosis (CF) lung disease, which is characterized by airway obstruction, chronic
bacterial infection, and an excessive inflammatory response, is responsible for most of the …

Covering: 1990 to 2009 Flavones are well known for their antioxidant activity, and are
unique in that they are present in the majority of fruits and vegetables. The majority of …

BACKGROUND: Cystic fibrosis (CF) is a recessively inherited condition caused by mutation
of the CFTR gene. Newborn infants with CF have raised levels of immuno-reactive …

Rationale: The respiratory tract is constantly exposed to airborne microorganisms.
Nevertheless, normal airways remain sterile without recruiting phagocytes. This innate …