Pathologies of the respiratory system such as lung infections, chronic inflammatory lung
diseases, and lung cancer are among the leading causes of morbidity and mortality, killing …

Gene therapy for cystic fibrosis (CF) is making encouraging progress into clinical trials.
However, further improvements in transduction efficiency are desired. To develop a novel …

Cystic fibrosis (CF) is a pleiotropic disease, originating from mutations in the CF
transmembrane conductance regulator (CFTR). Lung injuries inflicted by recurring infection …

Although it is generally recognized that cystic fibrosis transmembrane conductance regulator
(CFTR) contains a PSD-95/Disc-large/ZO-1 (PDZ)-binding motif at its COOH terminus, the …

Though the cause of cystic fibrosis (CF) pathology is understood to be the mutation of the
CFTR protein, it has been difficult to trace the exact mechanisms by which the pathology …

Interleukin (IL)-13 has been associated with asthma, allergic rhinitis, and chronic sinusitis,
all conditions where an imbalance in epithelial fluid secretion and absorption could impact …

The cystic fibrosis (CF) transmembrane conductance regulator (CFTR) protein is an
epithelial cell receptor for the outer core oligosaccharide of the Pseudomonas aeruginosa …

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) chloride
channel cause cystic fibrosis. The ΔF508 mutation produces defects in channel gating and …

Channelopathies, defined as diseases that are caused by mutations in genes encoding ion
channels, are associated with a wide variety of symptoms. Impaired chloride transport can …

The cystic fibrosis transmembrane conductance regulator (CFTR) 1 forms a Cl channel that
is an essential component of epithelial Cl transport systems in many organs, including the …