Mucins are major glycoprotein components of the mucus that coats the surfaces of cells
lining the respiratory, digestive, gastrointestinal and urogenital tracts. They function to …

In patients with cystic fibrosis (CF), the poor clearance of airway secretions promotes
recurrent cycles of pulmonary infection and inflammation. In recent years, novel drugs have …

Transepithelial anion secretion in many tissues depends upon the activity of basolateral
channels. Using monolayers of the Calu‐3 cell line, a human submucosal serous cell model …

Cystic fibrosis (CF) is caused by mutations in the CFTR chloride channel. Deletion of
phenylalanine 508 (F508del), the most frequent CF mutation, impairs CFTR trafficking and …

Cystic fibrosis transmembrane conductance regulator (CFTR) regulates both HCO 3−
secretion and HCO 3− salvage in secretory epithelia. At least two luminal transporters …

Cystic fibrosis transmembrane conductance regulator (CFTR) is an epithelial Cl–channel
expressed in luminal membranes of secretory and reabsorptive epithelia. CFTR plays a …

We investigated putative mechanisms by which nitric oxide modulates cystic fibrosis
transmembrane conductance regulator (CFTR) expression and function in epithelial cells …

Cystic fibrosis (CF) is a hereditary disease caused by mutations in the gene encoding the
chloride channel “cystic fibrosis transmembrane conductance regulator”(CFTR). The lack of …

Background Chronic constipation is a gastrointestinal functional disorder which affects
patient quality of life. Therefore, many studies were oriented to search herbal laxative …

The cystic fibrosis transmembrane conductance regulator (CFTR) is expressed in the fetal
lung, but during lung development it gradually disappears in cells of future alveolar spaces …