Alzheimer disease (AD) is the most common form of neurodegenerative disease, estimated
to contribute 60–70% of all cases of dementia worldwide. According to the prevailing …

Microglia activation is observed in various neurodegenerative diseases. Recent advances in
single-cell technologies have revealed that these reactive microglia were with high spatial …

Objective This study is to investigate the role of gut dysbiosis in triggering inflammation in
the brain and its contribution to Alzheimer's disease (AD) pathogenesis. Design We …

Alzheimer's disease (AD) pathologies were discovered in the accessible neurosensory
retina. However, their exact nature and topographical distribution, particularly in the early …

Several attempts have been made to treat Alzheimer's disease (AD) using anti-amyloid
strategies with disappointing results. It is clear that the “amyloid cascade hypothesis” alone …

The aging process is driven by interrelated mechanisms that lead to the emergence of
characteristic phenotypes that include changes in body composition, energy production and …

Neuroinflammation play an important role in Alzheimer's disease pathogenesis. Advances in
molecular imaging using positron emission tomography have provided insights into the time …

Severe amyloidosis and plaque-localized neuro-inflammation are key pathological features
of Alzheimer's disease (AD). In addition to astrocyte and microglial reactivity, emerging …

Inflammatory reactions could be both beneficial and detrimental to the brain, depending on
strengths of their activation in various stages of neurodegeneration. Mild activation of …

Gut dysbiosis contributes to Alzheimer's disease (AD) pathogenesis, and Bacteroides strains
are selectively elevated in AD gut microbiota. However, it remains unknown which …