Extracellular vesicles (EVs) have gained increasing recognition as significant regulators of
intercellular communication in various physiological and pathological processes. These …

Ferroptosis is a novel type of controlled cell death resulting from an imbalance between
oxidative harm and protective mechanisms, demonstrating significant potential in combating …

With the development of biotechnology, biomaterials have been rapidly developed and
shown great potential in bone regeneration therapy and bone tissue engineering …

The identification of new therapeutic targets and the development of innovative therapeutic
approaches are the most important challenges for osteosarcoma treatment. In fact, despite …

Matrine (MT) has shown promising efficacy in various cancers and chronic hepatitis;
however, its clinical application is limited because of its side effects. Our previous studies …

Currently, challenges such as chemotherapy resistance, resulting from preoperative and
postoperative chemotherapy, postoperative recurrence, and poor bone regeneration quality …

This novel radiolabeled chitosan nanoparticle, facilitated with curcumin, increased
doxorubicin cytotoxicity and radiosensitivity to MG-63 osteosarcoma cells in a three …

The hypoxic tumor microenvironment (TME) of osteosarcoma (OS) is the Achilles' heel of
oxygen-dependent photodynamic therapy (PDT), and tremendous challenges are …

Current treatments for orthopaedic illnesses frequently result in poor prognosis, treatment
failure, numerous relapses, and other unpleasant outcomes that have a significant impact on …

Objective: To explore the therapeutic mechanism of Mori Cortex against osteosarcoma (OS),
we conducted bioinformatics prediction followed by in vitro experimental validation …