Abstract Organs-on-chips (OoCs) are systems containing engineered or natural miniature
tissues grown inside microfluidic chips. To better mimic human physiology, the chips are …

Abstract The three-dimensional (3D) multicellular tumor spheroids (MCTs) model is
becoming an essential tool in cancer research as it expresses an intermediate complexity …

Cancer is a multifactorial disease that is responsible for 10 million deaths per year. The intra-
and inter-heterogeneity of malignant tumors make it difficult to develop single targeted …

Multicellular spheroids and organoids are promising in vitro 3D models in personalized
medicine and drug screening. They replicate the structural and functional characteristics of …

The construction of biomimetic vasculatures within the artificial tissue models or organs is
highly required for conveying nutrients, oxygen, and waste products, for improving the …

Cancer, one of the most dangerous diseases with a high mortality rate, has attracted much
attention and interest. Advances in tissue engineering and microfluidics have led to the …

Neuroblastoma is an extracranial solid tumor which develops in early childhood and still has
a poor prognosis. One strategy to increase cure rates is the identification of patient-specific …

As a full-fidelity simulation of human cells, tissues, organs, and even systems at the
microscopic scale, Organ-on-a-Chip (OOC) has significant ethical advantages and …

Previous studies have developed vascularized tumor spheroid models to demonstrate the
impact of intravascular flow on tumor progression and treatment. However, these models …

Cancer immunotherapy is the great breakthrough in cancer treatment as it displayed
prolonged progression-free survival over conventional therapies, yet, to date, in only a …