Oncogenic activation of the phosphatidylinositol-3-kinase (PI3K), protein kinase B
(PKB/AKT), and mammalian target of rapamycin (mTOR) pathway is a frequent event in …

Androgen deprivation therapy (ADT) and androgen receptor (AR)-targeted therapy are the
gold standard options for treating prostate cancer (PCa). These are initially effective, as …

Aims Prostate cancer is one of the most frequent causes of cancer death in men worldwide,
and novel drugs for prostate cancer therapies are still being developed. Palmitic acid is a …

Despite advances in prostate cancer diagnosis and management, morbidity from prostate
cancer remains high. Approximately 20% of men present with advanced or metastatic …

Loss of function of the PTEN tumour suppressor, resulting in dysregulated activation of the
phosphoinositide 3-kinase (PI3K) signalling network, is recognized as one of the most …

Prostate cancer is the most common cancer in men and the second most common cause of
cancer‐related deaths in men. Although, various drugs targeting the androgen receptor are …

Despite the existence of extensive clinical research and novel therapeutic treatments,
cancer remains undefeated and the significant cause of death worldwide. Cancer is a …

An increasing amount of data supports an inverse association between statin use and
cancer risk. The findings for prostate cancer, particularly advanced disease, are the most …

Chrysin is a natural flavone found in numerous plant extracts, honey, and propolis that has
multiple biological activities including anti‐cancer effects. Understanding of biological …

As water-soluble flavonoid derivatives, anthocyanidins and anthocyanins are the plants
pigments mostly rich in berries, pomegranate, grapes, and dark color fruits. Many bioactivity …