There is a pressing need for more effective nonaddictive treatment options for pain. Pain
signals are transmitted from the periphery into the spinal cord via dorsal root ganglion (DRG) …

Neuroinflammation is a major component in the transition to and perpetuation of neuropathic
pain states. Spinal neuroinflammation involves activation of TLR4, localized to enlarged …

In vitro models fill a vital niche in preclinical pain research, allowing detailed study of
molecular pathways, and in the case of humanised systems, providing a translational bridge …

Chemotherapy-induced peripheral neuropathy (CIPN) is a frequent, potentially irreversible
adverse effect of cytotoxic chemotherapy often leading to a reduction or discontinuation of …

Neuropathic pain in rodents can be driven by ectopic spontaneous activity (SA) generated
by sensory neurons in dorsal root ganglia (DRG). The recent demonstration that SA in …

Background and Purpose Paclitaxel produces a chemotherapy‐induced peripheral
neuropathy that persists in 50–60% of cancer patients upon treatment. Evidence from animal …

Nociceptive afferent signaling evoked by inflammation and nerve injury is mediated by the
opening of ligand-gated and voltagegated receptors or channels localized to cholesterol …

Paclitaxel-induced peripheral neuropathy (PIPN) is one of the common adverse effects
during the paclitaxel (PTX) treatment of cancer. In this study, we investigated the …

Neuropathic pain remains a challenge for many cancer patients who receive
chemotherapeutic treatment and who have limited and rarely effective options for pain …

Paclitaxel is a chemotherapeutic agent used to treat a wide range of malignant tumors.
Although it has anti-tumoral properties, paclitaxel also shows significant adverse effects on …