DNA methylation is a major control program that modulates gene expression in a plethora of
organisms. Gene silencing through methylation occurs through the activity of DNA …

In this paper we present cellular senescence as the ultimate driver of the aging process, as a
“causal nexus” that bridges microscopic subcellular damage with the phenotypic …

Replicative cellular senescence is an important tumor suppression mechanism and also
contributes to aging. Progression of both cancer and aging include significant epigenetic …

Altered DNA methylation and associated destabilization of genome integrity and function is
a hallmark of cancer. Replicative senescence is a tumour suppressor process that imposes …

The potential roles of epigenetic alterations in the pathogenesis of autoimmune rheumatic
diseases are raising great expectations among clinicians and researchers. Epigenetic …

The term cellular senescence was introduced more than five decades ago to describe the
state of growth arrest observed in aging cells. Since this initial discovery, the phenotypes …

Senescence is the end point of a complex cellular response that proceeds through a set of
highly regulated steps. Initially, the permanent cell-cycle arrest that characterizes …

Endogenous retroelements, transposons that mobilize through RNA intermediates, include
some of the most abundant repetitive sequences of the human genome, such as Alu and …

The increasing amount of nanotechnological products, found in our environment and those
applicable in engineering, material sciences and medicine has stimulated a growing interest …

Methyltransferase DNMT2 is suggested to be involved in the regulation of numerous
processes, however its biological significance and underlying molecular mechanisms …