There is a curious and paradoxic phenomenon, reliably demonstrated in animal models, that
consists of an increased sensitivity to pain that is apparently induced by the very opioid …

BACKGROUND: Failed back surgery syndrome (FBSS) is a challenging problem. One
treatment advocated to treat FBSS is epidural lysis of adhesions (LOA). The results of …

Background: The long term use of opioids for the treatment of pain leads to a group of
maladaptations which includes opioid-induced hyperalgesia (OIH). OIH typically resolves …

Objective Opioid tapering is recommended when risks of chronic opioid use outweigh
benefits. Little is known about patient characteristics or factors related to tapering success …

Objective: Calmare (Scrambler) therapy is a novel therapeutic modality that purports to
provide pain relief by “scrambling” afferent pain signals and replacing them with “non-pain” …

Chronic pain begins with acute pain. Physicians tend to classify pain by duration (acute vs
chronic) and mechanism (nociceptive, neuropathic and nociplastic). Although this taxonomy …

Chronic nonmalignant pain (CNMP), defined as persistent pain that is not attributable to a
potentially life-limiting condition and has a duration of at least 3 months, is widespread in the …

Methods: Adults with opioid-treated CLBP (N= 107) completed questionnaires assessing
pain, pain symptoms, and psychological measures. CPM and TS were evaluated as …

Methadone is a utilitarian opioid with multiple applications in anesthesiology, acute pain,
cancer pain, sickle cell disease, and opioid use disorder, in both adults and children …

Background Opioids are a mainstay for the treatment of chronic pain. Unfortunately, therapy-
limiting maladaptations such as loss of treatment effect (tolerance), and paradoxical opioid …