Type III secretion in Chlamydia
EA Rucks - Microbiology and Molecular Biology Reviews, 2023 - Am Soc Microbiol
Type III secretion systems (T3SSs) are utilized by Gram-negative pathogens to enhance
their pathogenesis. This secretion system is associated with the delivery of effectors through …
their pathogenesis. This secretion system is associated with the delivery of effectors through …
[HTML][HTML] Recent advances in genetic systems in obligate intracellular human-pathogenic bacteria
DJ Fisher, PA Beare - Frontiers in Cellular and Infection Microbiology, 2023 - frontiersin.org
The ability to genetically manipulate a pathogen is fundamental to discovering factors
governing host-pathogen interactions at the molecular level and is critical for devising …
governing host-pathogen interactions at the molecular level and is critical for devising …
Molecular Characterization of the ClpC AAA+ ATPase in the Biology of Chlamydia trachomatis
S Pan, AA Jensen, NA Wood, B Henrichfreise… - Mbio, 2023 - Am Soc Microbiol
Bacterial AAA+ unfoldases are crucial for bacterial physiology by recognizing specific
substrates and, typically, unfolding them for degradation by a proteolytic component. The c …
substrates and, typically, unfolding them for degradation by a proteolytic component. The c …
[HTML][HTML] ReporType: A Flexible Bioinformatics Tool for Targeted Loci Screening and Typing of Infectious Agents
H Cruz, M Pinheiro, V Borges - International Journal of Molecular …, 2024 - mdpi.com
In response to the pressing need for continuous monitoring of emergence and circulation of
pathogens through genomics, it is imperative to keep developing bioinformatics tools that …
pathogens through genomics, it is imperative to keep developing bioinformatics tools that …
[HTML][HTML] Advances in genetic manipulation of Chlamydia trachomatis
W Wan, D Li, D Li, J Jiao - Frontiers in Immunology, 2023 - frontiersin.org
Chlamydia trachomatis, one species of Chlamydia spp., has the greatest impact on human
health and is the main cause of bacterial sexually transmitted diseases and preventable …
health and is the main cause of bacterial sexually transmitted diseases and preventable …
A minimal replicon enables efficacious, species-specific gene deletion in Chlamydia and extension of gene knockout studies to the animal model of infection using …
KA Fields, MD Bodero, KR Scanlon… - Infection and …, 2022 - Am Soc Microbiol
The genus Chlamydia consists of diverse, obligate intracellular bacteria that infect various
animals, including humans. Although chlamydial species share many aspects of the typical …
animals, including humans. Although chlamydial species share many aspects of the typical …
[HTML][HTML] Bringing genetics to heretofore intractable obligate intracellular bacterial pathogens: Chlamydia and beyond
M Ölander, BS Sixt - PLoS Pathogens, 2022 - journals.plos.org
As their designation implies, obligate intracellular bacteria are microbes that have
developed lifestyles so closely entwined with the cells of the hosts they infect that they can …
developed lifestyles so closely entwined with the cells of the hosts they infect that they can …
Contributions of diverse models of the female reproductive tract to the study of Chlamydia trachomatis-host interactions
FC Walker, I Derré - Current Opinion in Microbiology, 2024 - Elsevier
Highlights•Chlamydia infections have damaging consequences on female reproductive
health.•Diverse model systems are required to understand Chlamydia-host …
health.•Diverse model systems are required to understand Chlamydia-host …
[HTML][HTML] Psittacosis: an underappreciated and often undiagnosed disease
ZF Dembek, JL Mothershead, AN Owens, T Chekol… - Pathogens, 2023 - mdpi.com
The bacterial agent Chlamydia psittaci, and the resulting disease of psittacosis, is a little-
known and underappreciated infectious disease by healthcare practitioners and in public …
known and underappreciated infectious disease by healthcare practitioners and in public …
Targeted repression of topA by CRISPRi reveals a critical function for balanced DNA topoisomerase I activity in the Chlamydia trachomatis developmental cycle
L Shen, L Gao, AR Swoboda, SP Ouellette - Mbio, 2024 - Am Soc Microbiol
Chlamydia trachomatis is an obligate intracellular bacterium that is responsible for the most
prevalent bacterial sexually transmitted infection. Changes in DNA topology in this pathogen …
prevalent bacterial sexually transmitted infection. Changes in DNA topology in this pathogen …