Introduction Cigarette smoking has major health implications and causes substantial
damage to all organ systems. Approximately one-third of men are active smokers worldwide …

Introduction Despite the ever-increasing occurrences of the coronavirus disease (COVID-19)
cases around the world, very few medications have been validated in the clinical trials to …

Sildenafil is a new approach to treat fetal growth restriction (FGR) and preeclampsia. We
performed a systematic meta-analysis to evaluate effects of sildenafil. Our search identified …

Real-world drug repurposing—the immediate “off-label” prescribing of drugs to address
urgent clinical needs—is a widely overlooked opportunity. Off-label prescribing (ie, for a …

Background SARS-CoV-2 seems to affect the regulation of pulmonary perfusion.
Hypoperfusion in areas of well-aerated lung parenchyma results in a ventilation–perfusion …

Background Recent studies have provided evidence for an important contribution of the
immune system in the pathophysiology of pulmonary arterial hypertension (PAH) and …

Abstract Background Coronavirus Disease 2019 (COVID-19) is a multi-systemic infection
caused by the novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), that …

Ethnopharmacological relevance Processing cow ghee (clarified butterfat) with therapeutic
herbs, ie ghrita, is recognized for augmenting the therapeutic efficacy of plant materials …

Selective phosphodiesterase 5 inhibitors, including sildenafil, tadalafil and vardenafil, are
widely-used in the treatment of erectile dysfunction and pulmonary arterial hypertension …

Interleukin-1 receptor-associated kinase-3 (IRAK3) is a critical checkpoint molecule of
inflammatory responses in the innate immune system. The pseudokinase domain of IRAK3 …