Telomere length as a marker of biological age: state-of-the-art, open issues, and future perspectives
A Vaiserman, D Krasnienkov - Frontiers in genetics, 2021 - frontiersin.org
Telomere shortening is a well-known hallmark of both cellular senescence and organismal
aging. An accelerated rate of telomere attrition is also a common feature of age-related …
aging. An accelerated rate of telomere attrition is also a common feature of age-related …
Telomeres and telomere length: a general overview
N Srinivas, S Rachakonda, R Kumar - Cancers, 2020 - mdpi.com
Telomeres are highly conserved tandem nucleotide repeats that include proximal double-
stranded and distal single-stranded regions that in complex with shelterin proteins afford …
stranded and distal single-stranded regions that in complex with shelterin proteins afford …
Determinants of telomere length across human tissues
K Demanelis, F Jasmine, LS Chen, M Chernoff, L Tong… - Science, 2020 - science.org
INTRODUCTION Telomeres are DNA-protein complexes located at the end of chromosomes
that protect chromosome ends from degradation and fusion. The DNA component of …
that protect chromosome ends from degradation and fusion. The DNA component of …
Association between COVID‐19 and telomere length: a bidirectional Mendelian randomization study
D Huang, S Lin, J He, Q Wang… - Journal of medical …, 2022 - Wiley Online Library
Several traditional observational studies suggested an association between COVID‐19 and
leukocyte telomere length (LTL), a biomarker for biological age. However, whether there …
leukocyte telomere length (LTL), a biomarker for biological age. However, whether there …
The association between stressors and telomeres in non‐human vertebrates: a meta‐analysis
Animal response to stressors such as harsh environmental conditions and demanding
biological processes requires energy generated through increased mitochondrial activity …
biological processes requires energy generated through increased mitochondrial activity …
Sex and gender differences research design for basic, clinical, and population studies: essentials for investigators
JW Rich-Edwards, UB Kaiser, GL Chen… - Endocrine …, 2018 - academic.oup.com
A sex-and gender-informed perspective increases rigor, promotes discovery, and expands
the relevance of biomedical research. In the current era of accountability to present data for …
the relevance of biomedical research. In the current era of accountability to present data for …
Severity of gastric intestinal metaplasia predicts the risk of gastric cancer: a prospective multicentre cohort study (GCEP)
Objective To investigate the incidence of gastric cancer (GC) attributed to gastric intestinal
metaplasia (IM), and validate the Operative Link on Gastric Intestinal Metaplasia (OLGIM) for …
metaplasia (IM), and validate the Operative Link on Gastric Intestinal Metaplasia (OLGIM) for …
Mediterranean diet and the hallmarks of ageing
Ageing is a multifactorial process associated with reduced function and increased risk of
morbidity and mortality. Recently, nine cellular and molecular hallmarks of ageing have …
morbidity and mortality. Recently, nine cellular and molecular hallmarks of ageing have …
Alcohol consumption and telomere length: Mendelian randomization clarifies alcohol's effects
Alcohol's impact on telomere length, a proposed marker of biological aging, is unclear. We
performed the largest observational study to date (in n= 245,354 UK Biobank participants) …
performed the largest observational study to date (in n= 245,354 UK Biobank participants) …
Telomere length and oxidative stress and its relation with metabolic syndrome components in the aging
G Gavia-García, J Rosado-Pérez, TL Arista-Ugalde… - Biology, 2021 - mdpi.com
Simple Summary A link between telomere length and some age-related diseases has been
identified, including metabolic syndrome. So far, there is no mechanism to explain the origin …
identified, including metabolic syndrome. So far, there is no mechanism to explain the origin …