Telomere length as a marker of biological age: state-of-the-art, open issues, and future perspectives

A Vaiserman, D Krasnienkov - Frontiers in genetics, 2021 - frontiersin.org
Telomere shortening is a well-known hallmark of both cellular senescence and organismal
aging. An accelerated rate of telomere attrition is also a common feature of age-related …

Telomeres and telomere length: a general overview

N Srinivas, S Rachakonda, R Kumar - Cancers, 2020 - mdpi.com
Telomeres are highly conserved tandem nucleotide repeats that include proximal double-
stranded and distal single-stranded regions that in complex with shelterin proteins afford …

Determinants of telomere length across human tissues

K Demanelis, F Jasmine, LS Chen, M Chernoff, L Tong… - Science, 2020 - science.org
INTRODUCTION Telomeres are DNA-protein complexes located at the end of chromosomes
that protect chromosome ends from degradation and fusion. The DNA component of …

Association between COVID‐19 and telomere length: a bidirectional Mendelian randomization study

D Huang, S Lin, J He, Q Wang… - Journal of medical …, 2022 - Wiley Online Library
Several traditional observational studies suggested an association between COVID‐19 and
leukocyte telomere length (LTL), a biomarker for biological age. However, whether there …

The association between stressors and telomeres in non‐human vertebrates: a meta‐analysis

M Chatelain, SM Drobniak, M Szulkin - Ecology letters, 2020 - Wiley Online Library
Animal response to stressors such as harsh environmental conditions and demanding
biological processes requires energy generated through increased mitochondrial activity …

Sex and gender differences research design for basic, clinical, and population studies: essentials for investigators

JW Rich-Edwards, UB Kaiser, GL Chen… - Endocrine …, 2018 - academic.oup.com
A sex-and gender-informed perspective increases rigor, promotes discovery, and expands
the relevance of biomedical research. In the current era of accountability to present data for …

Severity of gastric intestinal metaplasia predicts the risk of gastric cancer: a prospective multicentre cohort study (GCEP)

JWJ Lee, F Zhu, S Srivastava, SKK Tsao, C Khor… - Gut, 2022 - gut.bmj.com
Objective To investigate the incidence of gastric cancer (GC) attributed to gastric intestinal
metaplasia (IM), and validate the Operative Link on Gastric Intestinal Metaplasia (OLGIM) for …

Mediterranean diet and the hallmarks of ageing

OM Shannon, AW Ashor, F Scialo, G Saretzki… - European Journal of …, 2021 - nature.com
Ageing is a multifactorial process associated with reduced function and increased risk of
morbidity and mortality. Recently, nine cellular and molecular hallmarks of ageing have …

Alcohol consumption and telomere length: Mendelian randomization clarifies alcohol's effects

A Topiwala, B Taschler, KP Ebmeier, S Smith… - Molecular …, 2022 - nature.com
Alcohol's impact on telomere length, a proposed marker of biological aging, is unclear. We
performed the largest observational study to date (in n= 245,354 UK Biobank participants) …

Telomere length and oxidative stress and its relation with metabolic syndrome components in the aging

G Gavia-García, J Rosado-Pérez, TL Arista-Ugalde… - Biology, 2021 - mdpi.com
Simple Summary A link between telomere length and some age-related diseases has been
identified, including metabolic syndrome. So far, there is no mechanism to explain the origin …