E-cadherin is a transmembrane glycoprotein which connects epithelial cells together at
adherens junctions. In normal cells, E-cadherin exerts its tumour suppressing role mainly by …

Molecular analysis of invasive breast cancer and its precursors has furthered our
understanding of breast cancer progression. In the past few years, new multi‐step pathways …

E-cadherin and the associated catenin complex have been recognised as performing a key
role in cell adhesion. Loss of cell adhesion is seen as a key step in the cascade leading to …

Background Clinical decisions about atypical lobular hyperplasia are based on the belief
that later invasive breast-cancer risk is equal in both breasts. We aimed to show laterality …

We studied the pattern of E-cadherin expression in 183 invasive carcinomas (100 ductal, 42
lobular, 41 with mixed ductal and lobular features) and 198 in situ carcinomas (131 ductal …

Accumulating evidences indicate that p120 catenin, a member of the E-cadherin (E-
CD)/catenin adhesion complex, plays a role in tumor invasion. To establish the expression …

Background: National incidence rates for lobular and ductal breast cancers have not been
available previously. Evidence suggests that the increased risk of breast cancer associated …

BACKGROUND Incidence rates of ductal carcinoma in situ (DCIS) and lobular carcinoma in
situ (LCIS) have been rising, but little is known about which patients will develop invasive …

Atypical lobular hyperplasia (ALH) and lobular carcinoma in situ (LCIS) diagnosed in core
needle biopsy (CNB) are generally regarded as risk indicators for developing invasive …

Invasive lobular carcinoma (ILC) and lobular carcinoma in situ characteristically show loss of
E-cadherin expression and so immunohistochemistry for E-cadherin is being increasingly …