SARS-COV-2 has roused the scientific community with a call to action to combat the growing
pandemic. At the time of this writing, there are as yet no novel antiviral agents or approved …

The discovery of cytokines as key drivers of immune-mediated diseases has spurred efforts
to target their associated signalling pathways. Janus kinases (JAKs) are essential signalling …

Since December 2019, a viral pneumonia, named coronavirus disease 2019 (COVID-19),
from Wuhan, China, has swept the world. Although the case fatality rate is not high, the …

The Janus kinase/signal transduction and activator of transcription (JAK–STAT) signaling
pathway is implicated in the pathogenesis of inflammatory and autoimmune diseases …

Since the outbreak of COVID-19 many studies have been published showing possible
therapies, here the author discusses the end of stage disease related drugs, like …

Regular exercise reduces the risk of cancer and disease recurrence. Yet the mechanisms
behind this protection remain to be elucidated. In this study, tumor-bearing mice randomized …

Abstract Coronavirus disease-19 (COVID-19), a devastating respiratory illness caused by
SARS-associated coronavirus-2 (SARS-CoV-2), has already affected over 64 million people …

Cytokines are major drivers of autoimmunity, and biologic agents targeting cytokines have
revolutionized the treatment of immune-mediated diseases. Despite the effectiveness of …

The majority of COVID-19 survivors experience long-term neuropsychiatric symptoms such
as fatigue, sleeping difficulties, depression and anxiety. We propose that neuroimmune …

Abstract Interleukin-6 (IL-6) is a multifunctional cytokine with well-defined pro-and anti-
inflammatory properties. Although only small amounts in the picogram range can be …