In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway,
termed the integrated stress response (ISR), to restore cellular homeostasis. The core event …

Activating transcription factor 4 (ATF4) is a stress-induced transcription factor that is
frequently upregulated in cancer cells. ATF4 controls the expression of a wide range of …

Cells have a constant turnover of proteins that recycle most amino acids over time. Net loss
is mainly due to amino acid oxidation. Homeostasis is achieved through exchange of …

Protein misfolding in the endoplasmic reticulum (ER) leads to cell death through PERK-
mediated phosphorylation of eIF2α, although the mechanism is not understood. ChIP-seq …

Homeostasis is one of the fundamental concepts in physiology. Despite remarkable
progress in our molecular understanding of amino acid transport, metabolism and signaling …

Enhanced fibroblast growth factor 21 (FGF21) production and circulation has been linked to
the metabolic adaptation to starvation. Here, we demonstrated that hepatic FGF21 …

Asparagine synthetase (ASNS) converts aspartate and glutamine to asparagine and
glutamate in an ATP-dependent reaction. ASNS is present in most, if not all, mammalian …

Simple Summary L-asparaginase (L-ASNase) therapy is key for achieving the very high cure
rate of pediatric acute lymphoblastic leukemia (ALL), yet its use is mostly confined to this …

Arginine, one among the 20 most common natural amino acids, has a pivotal role in cellular
physiology as it is being involved in numerous cellular metabolic and signaling pathways …

How early events in effector T cell (T EFF) subsets tune memory T cell (T MEM) responses
remains incompletely understood. Here, we systematically investigated metabolic factors in …