Validated alternative test methods are urgently needed for safety testing of drugs, chemicals
and cosmetics. Whereas some animal tests for topical toxicity have been successfully …

Prolonged use of immunosuppressant medications is occasionally seen in infertile men with
chronic inflammatory conditions; autoimmune disorders; or an organ or hematopoietic stem …

In this review, genotoxic and mutagenic effects of teratogenic chemical agents in both rat
and mouse have been reviewed. Of these chemicals, 97 are drugs and 33 are pesticides or …

ADHD Attention deficit hyperactivity disorder ART Assisted reproductive technology ASA
Antisperm antibodies BMI Body mass index BPH Benign prostate hyperplasia BTB Blood …

Cancer treatment can have long-term side effects in cured patients and infertility is one of
them. Given the urgency of diagnosis in children with cancer, the toxicity of treatments on the …

This study was performed to investigate the effects of exposure to vincristine (VCR) alone (1
mg kg− 1 or 2 mg kg− 1) and in combination with X-rays (0.25 Gy+ 1 mg kg− 1 VCR or 1.00 …

Vinblastine, a cytotoxic anti-neoplastic drug and a known mitotic spindle inhibitor, has
reportedly induced numerical and structural alterations in chromosome complements of …

目的通过对小鼠睾丸的定量组织学研究, 观察丝裂霉素C 等6 种抗肿瘤药物对小鼠睾丸生精过程
的影响. 方法制作小鼠睾丸组织切片, 显微镜下观察, 记录第Ⅶ 相细精管的精原细胞数及第Ⅳ …

This study was designed to evaluate the cytotoxic, genotoxic effects of the aqueous extract of
Catharanthus roseus leaves on the somatic and germ cells of Swiss albino mice Mus …

La préservation de la fertilité des enfants présentant un cancer est depuis plusieurs années
devenue uneétape importante dans la prise en charge de la qualité de vie après le cancer …