Huntington's disease is an inherited neurodegenerative disease described 150 years ago
by George Huntington. The genetic defect was identified in 1993 to be an expanded CAG …

Ischemic stroke (IS) is one of the most fatal diseases. Neuroimmunity, inflammation, and
oxidative stress play important roles in various complex mechanisms of IS. In particular, the …

Cannabinoid Receptor 2 (CB2) is a G protein-coupled receptor (GPCR) with considerable,
though as yet unrealised, therapeutic potential. Promising preclinical data supports the …

Microglia are resident immune cells of the brain that survey the microenvironment, provide
trophic support to neurons, and clear debris to maintain homeostasis and healthy brain …

We present the synthesis and characterization of merged human butyrylcholinesterase (h
BChE) inhibitor/cannabinoid receptor 2 (h CB2R) ligands for the treatment of …

Inflammation and oxidative stress are interlinked and interdependent processes involved in
many chronic diseases, including neurodegeneration, diabetes, cardiovascular diseases …

Dentate gyrus of the hippocampus continuously gives rise to new neurons, namely, adult-
born granule cells, which contribute to conferring plasticity to the mature brain throughout …

Alzheimer's disease (AD) is the leading cause of dementia in aged population. Oxidative
stress and neuroinflammation play important roles in the pathogenesis of AD. Investigation …

Neurological diseases are complex diseases affecting the brain and spinal cord, with
numerous etiologies and pathogenesis not yet fully elucidated. Tripterygium wilfordii Hook …

The present study aimed to investigate the effect of corticolimbic cannabinoid CB1 receptors
activity on memory impairment in the intracerebroventricular (ICV)-streptozotocin (STZ) …