Discovered more than 30 years ago, the angiotensin AT2 receptor (AT2R) has evolved from
a binding site with unknown function to a firmly established major effector within the …

Metabolic syndrome (MS) is not a single disease but a cluster of metabolic disorders
associated with increased risk for development of diabetes mellitus and its complications …

The renin-angiotensin system (RAS) has been recognized as a crucial contributor to the
development of liver fibrosis, and AT2R, an essential component of RAS, is involved in the …

Coffee and cocoa manufacturing produces large amounts of waste. Generated by-products
contain bioactive compounds with antioxidant and anti-inflammatory properties, suitable for …

Aim In addition to functioning as an energy sensor switch, AMPK plays a key role in the
maintenance of cardiovascular homeostasis. However, obesity disrupts AMPK signaling …

The renin‐angiotensin system (RAS) plays a key role in blood pressure regulation. The RAS
is a complex interconnected system composed of two axes with opposite effects. The …

Introduction Stroke is a major cause of death and disability and its incidence is linearly
increased with the elevation of blood pressure (BP) and the advancement of age in both …

The angiotensin II type 2 receptor (AT2R) exerts vasorelaxant, anti‐inflammatory, and
antioxidant properties. In obesity, its activation counterbalances the adverse cardiovascular …

Background: Gestational intermittent hypoxia (GIH), a hallmark of maternal obstructive sleep
apnea, sex-differentially causes hypertension and endothelial dysfunction in adult male …

Kidney disease currently affects one in seven American adults, with over 130,000 newly
diagnosed adults in 2019 alone. Although there are several risk factors attributed to the …