Sex differences in Alzheimer disease—the gateway to precision medicine

MT Ferretti, MF Iulita, E Cavedo, PA Chiesa… - Nature Reviews …, 2018 - nature.com
Alzheimer disease (AD) is characterized by wide heterogeneity in cognitive and behavioural
syndromes, risk factors and pathophysiological mechanisms. Addressing this phenotypic …

[PDF][PDF] The neurovascular unit coming of age: a journey through neurovascular coupling in health and disease

C Iadecola - Neuron, 2017 - cell.com
The concept of the neurovascular unit (NVU), formalized at the 2001 Stroke Progress
Review Group meeting of the National Institute of Neurological Disorders and Stroke …

Factors associated with healthy aging in Latin American populations

H Santamaria-Garcia, A Sainz-Ballesteros… - Nature Medicine, 2023 - nature.com
Latin American populations may present patterns of sociodemographic, ethnic and cultural
diversity that can defy current universal models of healthy aging. The potential combination …

Reconstruction of the human blood–brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes

JW Blanchard, M Bula, J Davila-Velderrain, LA Akay… - Nature medicine, 2020 - nature.com
In Alzheimer's disease, amyloid deposits along the brain vasculature lead to a condition
known as cerebral amyloid angiopathy (CAA), which impairs blood–brain barrier (BBB) …

Imaging the evolution and pathophysiology of Alzheimer disease

W Jagust - Nature Reviews Neuroscience, 2018 - nature.com
Technologies for imaging the pathophysiology of Alzheimer disease (AD) now permit
studies of the relationships between the two major proteins deposited in this disease …

Cerebral small vessel disease: from a focal to a global perspective

A Ter Telgte, EMC Van Leijsen, K Wiegertjes… - Nature Reviews …, 2018 - nature.com
Cerebral small vessel disease (SVD) is commonly observed on neuroimaging among
elderly individuals and is recognized as a major vascular contributor to dementia, cognitive …

Preclinical Alzheimer's disease: definition, natural history, and diagnostic criteria

B Dubois, H Hampel, HH Feldman, P Scheltens… - Alzheimer's & …, 2016 - Elsevier
During the past decade, a conceptual shift occurred in the field of Alzheimer's disease (AD)
considering the disease as a continuum. Thanks to evolving biomarker research and …

Topological sound

X Zhang, M Xiao, Y Cheng, MH Lu… - Communications …, 2018 - nature.com
Recently, we witnessed a tremendous effort to conquer the realm of acoustics as a possible
playground to test with topologically protected sound wave propagation. In this article, we …

Inflammation and cerebral small vessel disease: a systematic review

A Low, E Mak, JB Rowe, HS Markus, JT O'Brien - Ageing research reviews, 2019 - Elsevier
Inflammation is increasingly implicated as a risk factor for dementia, stroke, and small vessel
disease (SVD). However, the underlying mechanisms and causative pathways remain …

Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics

MA Petersen, JK Ryu, K Akassoglou - Nature Reviews Neuroscience, 2018 - nature.com
The blood coagulation protein fibrinogen is deposited in the brain in a wide range of
neurological diseases and traumatic injuries with blood–brain barrier (BBB) disruption …