Lewy bodies, iron, inflammation and neuromelanin: pathological aspects underlying Parkinson's disease

P Riederer, T Nagatsu, MBH Youdim, M Wulf… - Journal of Neural …, 2023 - Springer
Since the description of some peculiar symptoms by James Parkinson in 1817, attempts
have been made to define its cause or at least to enlighten the pathology of “Parkinson's …

Constipation in Parkinson's disease

EMM Quigley - Seminars in Neurology, 2023 - thieme-connect.com
Constipation is one of the most common gastrointestinal features of Parkinson's disease
(PD), occurring in over 50% of all PD patients during the course of their disease …

Caenorhabditis elegans RAC1/ced-10 mutants as a new animal model to study very early stages of Parkinson's disease

A Muñoz-Juan, N Benseny-Cases, S Guha… - Progress in …, 2024 - Elsevier
Patients with Parkinson's disease (PD) display non-motor symptoms arising prior to the
appearance of motor signs and before a clear diagnosis. Motor and non-motor symptoms …

Association of laxatives use with incident dementia and modifying effect of genetic susceptibility: a population-based cohort study with propensity score matching

J Feng, N Zheng, X Fan, S Li, Y Jiang, X Yi, H Yang - BMC geriatrics, 2023 - Springer
Background Constipation was associated with incidence of dementia and cognitive decline.
Laxatives are the mainstay of constipation management and are commonly used among …

Alpha Synuclein Toxicity and Non-motor Parkinson's

GM Mazzotta, C Conte - 2024 - preprints.org
Parkinson's disease (PD) is a common multisystem neurodegenerative disorder affecting
1% of the population above 60 years. The main neuropathological features of PD are the …

Predicting Depression in Parkinson's Disease Using Commonly Available PD Questionnaires

E Camerucci, KE Lyons, R Pahwa - Journal of clinical medicine, 2024 - mdpi.com
Background: Depression is common in patients with Parkinson's disease (PD) and
significantly impacts both the patients and their caregivers. The associations between …