Ca2+-release channels are giant membrane proteins that control the release of Ca2+ from
the endoplasmic and sarcoplasmic reticulum. The two members, ryanodine receptors …

Abstract Necrostatin-1 (Nec-1) is a RIP1-targeted inhibitor of necroptosis, a form of
programmed cell death discovered and investigated in recent years. There are already …

Junctophilins (JPHs) comprise a family of structural proteins that connect the plasma
membrane to intracellular organelles such as the endo/sarcoplasmic reticulum (ER/SR) …

Abstract Sustained Ca 2+/calmodulin-dependent kinase II (CaMKII) activation plays a central
role in the pathogenesis of a variety of cardiac diseases. Emerging evidence suggests …

Calcium/calmodulin-dependent protein kinase II (CaMKII) has emerged as key enzyme in
many cardiac pathologies, especially heart failure (HF), myocardial infarction and …

Calcium dynamics is central in cardiac physiology, as the key event leading to the excitation-
contraction coupling (ECC) and relaxation processes. The primary function of Ca2+ in the …

Background. Heat shock protein 70 (Hsp70) has been shown to exert cardioprotection.
Intracellular calcium ([Ca2+] i) overload induced by p38 mitogen‐activated protein kinase …

Heart failure is a serious global health challenge, affecting more than 6.2 million people in
the United States and is projected to reach over 8 million by 2030. Independent of etiology …

Inflammation is a physiological process by which the body responds to external insults and
stress conditions, and it is characterized by the production of pro-inflammatory mediators …

Abstract Deletion of Ca 2+/calmodulin-dependent protein kinase II delta (CaMKIIδ) has been
shown to protect against in vivo ischemia/reperfusion (I/R) injury. It remains unclear which …