The biology of glial cells and their complex roles in Alzheimer's disease: new opportunities in therapy

SSR Nirzhor, RI Khan, S Neelotpol - Biomolecules, 2018 - mdpi.com
Even though Alzheimer's disease (AD) is of significant interest to the scientific community, its
pathogenesis is very complicated and not well-understood. A great deal of progress has …

ABCA7 mediates phagocytic clearance of amyloid-β in the brain

YH Fu, JHT Hsiao, G Paxinos… - Journal of …, 2016 - content.iospress.com
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by dementia and
abnormal deposits of aggregated amyloid-β in the brain. Recent genome-wide association …

The choroid plexus transcriptome reveals changes in type I and II interferon responses in a mouse model of Alzheimer's disease

S Dá Mesquita, AC Ferreira, F Gao, G Coppola… - Brain, behavior, and …, 2015 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a marked
decline in cognition and memory function. Increasing evidence highlights the essential role …

Glial alterations from early to late stages in a model of A lzheimer's disease: Evidence of autophagy involvement in A β internalization

C Pomilio, P Pavia, RM Gorojod, A Vinuesa… - …, 2016 - Wiley Online Library
Alzheimer's disease (AD) is a progressive neurodegenerative disease without effective
therapy. Brain amyloid deposits are classical histopathological hallmarks that generate an …

Whole-body vibration ameliorates glial pathological changes in the hippocampus of hAPP transgenic mice, but does not affect plaque load

T Oroszi, E Geerts, R Rajadhyaksha, C Nyakas… - Behavioral and Brain …, 2023 - Springer
Background Alzheimer's disease (AD) is the core cause of dementia in elderly populations.
One of the main hallmarks of AD is extracellular amyloid beta (Aβ) accumulation (APP …

Aging-dependent changes in the cellular composition of the mouse brain and spinal cord

Y Fu, Y Yu, G Paxinos, C Watson, Z Rusznák - Neuroscience, 2015 - Elsevier
Although the impact of aging on the function of the central nervous system is known, only a
limited amount of information is available about accompanying changes affecting the …

Inhibition of hematopoietic cell kinase dysregulates microglial function and accelerates early stage Alzheimer's disease‐like neuropathology

SL Lim, DN Tran, J Zumkehr, C Chen, S Ghiaar, Z Kieu… - Glia, 2018 - Wiley Online Library
Emerging evidence have posited that dysregulated microglia impair clearance and
containment of amyloid‐β (Aβ) species in the brain, resulting in aberrant buildup of Aβ and …

[HTML][HTML] Odor enrichment increases hippocampal neuron numbers in mouse

Z Rusznák, G Sengul, G Paxinos… - Experimental …, 2018 - ncbi.nlm.nih.gov
The hippocampus and olfactory bulb incorporate new neurons migrating from neurogenic
regions in the brain. Hippocampal atrophy is evident in numerous neurodegenerative …

Analysis of the time-dependent changes of phospholipids in the brain regions of a mouse model of Alzheimer's disease

MA Haque, N Omori, AM Sheikh, S Yano, H Osago… - Brain Research, 2023 - Elsevier
Phospholipid levels are reported to be decreased in Alzheimer's disease (AD). For a better
understanding, we investigated the time-dependent changes of phospholipids species in a …

iTRAQ-based proteomic analysis of APPSw, Ind mice provides insights into the early changes in Alzheimer's disease

N Li, P Hu, T Xu, H Chen, X Chen, J Hu… - Current Alzheimer …, 2017 - ingentaconnect.com
Background: Several proteins have been identified as potential diagnostic biomarkers in
imaging, genetic, or proteomic studies in Alzheimer disease (AD) patients and mouse …