The biology of glial cells and their complex roles in Alzheimer's disease: new opportunities in therapy
Even though Alzheimer's disease (AD) is of significant interest to the scientific community, its
pathogenesis is very complicated and not well-understood. A great deal of progress has …
pathogenesis is very complicated and not well-understood. A great deal of progress has …
ABCA7 mediates phagocytic clearance of amyloid-β in the brain
YH Fu, JHT Hsiao, G Paxinos… - Journal of …, 2016 - content.iospress.com
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by dementia and
abnormal deposits of aggregated amyloid-β in the brain. Recent genome-wide association …
abnormal deposits of aggregated amyloid-β in the brain. Recent genome-wide association …
The choroid plexus transcriptome reveals changes in type I and II interferon responses in a mouse model of Alzheimer's disease
S Dá Mesquita, AC Ferreira, F Gao, G Coppola… - Brain, behavior, and …, 2015 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a marked
decline in cognition and memory function. Increasing evidence highlights the essential role …
decline in cognition and memory function. Increasing evidence highlights the essential role …
Glial alterations from early to late stages in a model of A lzheimer's disease: Evidence of autophagy involvement in A β internalization
C Pomilio, P Pavia, RM Gorojod, A Vinuesa… - …, 2016 - Wiley Online Library
Alzheimer's disease (AD) is a progressive neurodegenerative disease without effective
therapy. Brain amyloid deposits are classical histopathological hallmarks that generate an …
therapy. Brain amyloid deposits are classical histopathological hallmarks that generate an …
Whole-body vibration ameliorates glial pathological changes in the hippocampus of hAPP transgenic mice, but does not affect plaque load
T Oroszi, E Geerts, R Rajadhyaksha, C Nyakas… - Behavioral and Brain …, 2023 - Springer
Background Alzheimer's disease (AD) is the core cause of dementia in elderly populations.
One of the main hallmarks of AD is extracellular amyloid beta (Aβ) accumulation (APP …
One of the main hallmarks of AD is extracellular amyloid beta (Aβ) accumulation (APP …
Aging-dependent changes in the cellular composition of the mouse brain and spinal cord
Although the impact of aging on the function of the central nervous system is known, only a
limited amount of information is available about accompanying changes affecting the …
limited amount of information is available about accompanying changes affecting the …
Inhibition of hematopoietic cell kinase dysregulates microglial function and accelerates early stage Alzheimer's disease‐like neuropathology
SL Lim, DN Tran, J Zumkehr, C Chen, S Ghiaar, Z Kieu… - Glia, 2018 - Wiley Online Library
Emerging evidence have posited that dysregulated microglia impair clearance and
containment of amyloid‐β (Aβ) species in the brain, resulting in aberrant buildup of Aβ and …
containment of amyloid‐β (Aβ) species in the brain, resulting in aberrant buildup of Aβ and …
[HTML][HTML] Odor enrichment increases hippocampal neuron numbers in mouse
The hippocampus and olfactory bulb incorporate new neurons migrating from neurogenic
regions in the brain. Hippocampal atrophy is evident in numerous neurodegenerative …
regions in the brain. Hippocampal atrophy is evident in numerous neurodegenerative …
Analysis of the time-dependent changes of phospholipids in the brain regions of a mouse model of Alzheimer's disease
Phospholipid levels are reported to be decreased in Alzheimer's disease (AD). For a better
understanding, we investigated the time-dependent changes of phospholipids species in a …
understanding, we investigated the time-dependent changes of phospholipids species in a …
iTRAQ-based proteomic analysis of APPSw, Ind mice provides insights into the early changes in Alzheimer's disease
N Li, P Hu, T Xu, H Chen, X Chen, J Hu… - Current Alzheimer …, 2017 - ingentaconnect.com
Background: Several proteins have been identified as potential diagnostic biomarkers in
imaging, genetic, or proteomic studies in Alzheimer disease (AD) patients and mouse …
imaging, genetic, or proteomic studies in Alzheimer disease (AD) patients and mouse …