Cacna1c haploinsufficiency lacks effects on adult hippocampal neurogenesis and volumetric properties of prefrontal cortex and hippocampus in female rats

TM Redecker, TM Kisko, M Wöhr… - Physiology & Behavior, 2020 - Elsevier
The cross-disorder risk gene CACNA1C is strongly involved in the etiology of all major
neuropsychiatric disorders, with women often being more affected by CACNA1C mutations …

Early in vivo effects of the human mutant amyloid-β protein precursor (haβppswind) on the mouse olfactory bulb

Z Rusznak, WS Kim, JHT Hsiao… - Journal of …, 2016 - content.iospress.com
The amyloid-β protein precursor (AβPP) has long been linked to Alzheimer's disease (AD).
Using J20 mice, which express human AβPP with Swedish and Indiana mutations, we …

蛋白质组学对于阿尔茨海默症诊断标记物筛选的研究进展

李楠, 许均瑜 - 基因组学与应用生物学, 2016 - biopublisher.cn
摘要阿尔茨海默症, 简称AD (Alzheimer's Disease), 是一类神经退行性疾病, 主要发作于65
岁老年人群中, 患者会出现认知障碍, 记忆缺失, 言语障碍, 抑郁, 焦躁等症状 …

The complex effects of miR-146a in the pathogenesis of Alzheimer's disease

Y Long, J Liu, Y Wang, H Guo, G Cui - Neural Regeneration Research - journals.lww.com
Alzheimer's disease is a neurodegenerative disorder characterized by cognitive dysfunction
and behavioral abnormalities. Neuroinflammatory plaques formed through the extracellular …

[PDF][PDF] Whole-Body Vibration ameliorates astroglial pathological changes in the hippocampus of hAPP transgenic mice, but does not affect plaque load and microglia …

T Oroszi, E Geerts, R Rajadhyaksha… - The effects of whole …, 2023 - research.rug.nl
Background: Alzheimer's disease (AD) is the core cause of dementia in elderly populations.
One of the main hallmarks of AD is extracellular amyloid beta (Aβ) accumulation (APP …

Social Factors and Alzheimer's Disease: Navigating this Two-Way Street using Mouse Models

S Lanooij - 2024 - research.rug.nl
Alzheimer's Disease (AD) is the most common cause of dementia. Multiple factors can
contribute to the development of this disorder, including genetics predispositions, activity …

Effekte der Cacna1c Haploinsuffizienz auf Sozialverhalten und adulte hippocampale Neurogenese bei Ratten

TM Redecker - 2020 - archiv.ub.uni-marburg.de
Genomweite Assoziationsstudien liefern überzeugende Hinweise darauf, dass das
Risikogen CACNA1C an der Ätiologie der wichtigsten neuropsychiatrischen Störungen wie …