Locomotion results from intricate dynamic interactions between a central program and
feedback mechanisms. The central program relies fundamentally on a genetically …

Neural networks in the spinal cord, referred to as “central pattern generators”(CPGs), are
capable of producing rhythmic movements, such as swimming, walking, and hopping, even …

After spinal cord injury (SCI), various sensorimotor functions can recover, ranging from
simple spinal reflexes to more elaborate motor patterns, such as locomotion. Locomotor …

In the walking system of the cat, feedback from muscle proprioceptors establishes the timing
of major phase transitions in the motor pattern, contributes to the production of burst activity …

▪ Abstract Activity-dependent plasticity occurs in the spinal cord throughout life. Driven by
input from the periphery and the brain, this plasticity plays an important role in the …

▪ Abstract Motor systems can adapt rapidly to changes in external conditions and to
switching of internal goals. They can also adapt slowly in response to training, alterations in …

The production and control of complex motor functions are usually attributed to central brain
structures such as cortex, basal ganglia and cerebellum. In traditional schemes the spinal …

Peripheral nerve researchers frequently use the rat sciatic nerve crush as a model for
axonotmesis. Unfortunately, studies from various research groups report results from …

Walking is a key motor behaviour of limbed animals, executed by contraction of functionally
antagonistic muscle groups during swing and stance phases. Nevertheless, neuronal …

Motivated by the challenge of improving neuroprosthetic devices, the authors review current
knowledge relating to harnessing the potential of spinal neural circuits, such as reflexes and …