Hedgehog signaling underlying tendon and enthesis development and pathology

F Fang, MK Sup, A Luzzi, X Ferrer, S Thomopoulos - Matrix Biology, 2022 - Elsevier
Hedgehog (Hh) signaling has been widely acknowledged to play essential roles in many
developmental processes, including endochondral ossification and growth plate …

[HTML][HTML] How has molecular biology enhanced our undertaking of axSpA and its management

M Fatica, A D'Antonio, L Novelli, P Triggianese… - Current rheumatology …, 2023 - Springer
Purpose This review aims at investigating pathophysiological mechanisms in
spondyloarthritis (SpA). Analysis of genetic factors, immunological pathways, and …

Exosomes derived from microRNA‐21 overexpressed adipose tissue‐derived mesenchymal stem cells alleviate spine osteoporosis in ankylosing spondylitis mice

L Hu, Z Guan, C Tang, G Li… - Journal of Tissue …, 2022 - Wiley Online Library
Abstract MicroRNA‐21 (miR‐21) can induce proliferation and differentiation of mesenchymal
stem cells (MSCs) to promote bone formation, we therefore aimed to investigate whether …

[HTML][HTML] Bone Involvement in Rheumatoid Arthritis and Spondyloartritis: An Updated Review

F Orsini, C Crotti, G Cincinelli, R Di Taranto, A Amati… - Biology, 2023 - mdpi.com
Simple Summary Chronic inflammatory arthritis, such as rheumatoid arthritis (RA) and
spondyloarthritis (SpA), often have a significant impact on bone tissue, where bone is not …

[HTML][HTML] Effects of biological/targeted therapies on bone mineral density in inflammatory arthritis

TL Chen, KH Chang, KY Su - International Journal of Molecular Sciences, 2022 - mdpi.com
Inflammatory arthritis has been reported to be associated with the development of
osteoporosis. Recent research has investigated the mechanisms of bone metabolism in …

[HTML][HTML] Hounsfield Units measured in low dose CT reliably assess vertebral trabecular bone density changes over two years in axial spondyloarthritis

ML Marques, NP da Silva, D van der Heijde… - Seminars in Arthritis and …, 2023 - Elsevier
Objectives To describe low dose Computed Tomography (ldCT) Hounsfield Units (HU) two-
year change-from-baseline values (expressing trabecular bone density changes) and …

Low-dose CT hounsfield units: a reliable methodology for assessing vertebral bone density in radiographic axial spondyloarthritis

ML Marques, NP da Silva, D van der Heijde… - RMD open, 2022 - rmdopen.bmj.com
Objective Studying vertebral bone loss in radiographic axial spondyloarthritis (r-axSpA) has
been challenging due to ectopic bone formation. We cross-sectionally analysed low-dose …

Age-stratified trends in the progression of spinal radiographic damage in patients with ankylosing spondylitis: a longitudinal study

TH Lee, BS Koo, B Nam, YJ Kim… - Therapeutic …, 2022 - journals.sagepub.com
Objective: The objective of this study was to investigate spinal radiographic progression in
specific age ranges of ankylosing spondylitis (AS) patients. Methods: Longitudinal data for …

The role of the multidisciplinary team in the management of psoriatic arthritis

DR Jadon, PS Helliwell - Musculoskeletal Care, 2022 - Wiley Online Library
Psoriatic arthritis (PsA) has a heterogenous clinical phenotype with manifestations in a
number of different organs and systems. Whilst PsA is typified by enthesitis, synovitis and …

Both ASDAS and ADC are associated with spinal mobility in active axial spondyloarthritis: A comparison between early and later disease

HY Chung, SCW Chan, KH Lee… - International Journal …, 2022 - Wiley Online Library
Objective Using diffusion‐weighted imaging (DWI)‐derived apparent diffusion coefficient
(ADC), we aimed to determine the relationship between intensity of spinal inflammation and …