Acute respiratory distress syndrome (ARDS) is characterized by a rapid‐onset respiratory
failure with a mortality rate of approximately 40%. This physiologic inflammatory process is …

With this change in paradigm, come additional challenges and consideration in study design
that depends not only on the intervention but also whether the intervention aims for a …

Background Antiplatelet agents are commonly used for cardiovascular diseases, but their
pleiotropic effects in critically ill patients are controversial. We therefore performed a meta …

Transfusion-related acute lung injury (TRALI) may be induced by plasma, platelet
concentrates and red blood cell concentrates. The mechanism leading to TRALI is thought to …

In vitro circulation (cardiopulmonary bypass, CPB) has been widely used in heart surgery. In
the past, it was believed that the reduction of platelet count and impaired platelet function …

Background A myriad of trauma indices has been validated to predict probability of trauma
survival. We aimed to compare the performance of commonly used indices for the …

Recent improvements in clinical care delivery have been associated with a decrease in the
incidence of hospital-acquired ARDS. Despite the initial challenges, research in ARDS …

The development of acute respiratory distress syndrome (ARDS) carries significant risk of
morbidity and mortality. To date, pharmacological therapy has been largely ineffective for …

Acute respiratory distress syndrome (ARDS) is a common, lethal, and morbid respiratory
complication primarily seen in the setting of major trauma and infection. Despite advances in …

Mechanical ventilation (MV) is the main supportive treatment in respiratory failure due to
different etiologies. However, MV might aggravate ventilator-associated lung injury (VALI) …