The molecular hallmarks of the serrated pathway in colorectal cancer
Colorectal cancer (CRC) is a leading cause of cancer death worldwide. It includes different
subtypes that differ in their clinical and prognostic features. In the past decade, in addition to …
subtypes that differ in their clinical and prognostic features. In the past decade, in addition to …
Serrated lesions of the colorectum: review and recommendations from an expert panel
Serrated lesions of the colorectum are the precursors of perhaps one-third of colorectal
cancers (CRCs). Cancers arising in serrated lesions are usually in the proximal colon, and …
cancers (CRCs). Cancers arising in serrated lesions are usually in the proximal colon, and …
British Society of Gastroenterology position statement on serrated polyps in the colon and rectum
Serrated polyps have been recognised in the last decade as important premalignant lesions
accounting for between 15% and 30% of colorectal cancers. There is therefore a clinical …
accounting for between 15% and 30% of colorectal cancers. There is therefore a clinical …
Role of the serrated pathway in colorectal cancer pathogenesis
B Leggett, V Whitehall - Gastroenterology, 2010 - Elsevier
The “serrated neoplastic pathway” describes the progression of serrated polyps, including
sessile serrated adenomas and traditional serrated adenomas, to colorectal cancer. The …
sessile serrated adenomas and traditional serrated adenomas, to colorectal cancer. The …
DNA methyltransferases, DNA damage repair, and cancer
B Jin, KD Robertson - Epigenetic alterations in oncogenesis, 2012 - Springer
The maintenance DNA methyltransferase (DNMT) 1 and the de novo methyltransferases
DNMT3A and DNMT3B are all essential for mammalian development. DNA methylation …
DNMT3A and DNMT3B are all essential for mammalian development. DNA methylation …
Classification of colorectal cancer based on correlation of clinical, morphological and molecular features
JR Jass - Histopathology, 2007 - Wiley Online Library
Over the last 20 years it has become clear that colorectal cancer (CRC) evolves through
multiple pathways. These pathways may be defined on the basis of two molecular …
multiple pathways. These pathways may be defined on the basis of two molecular …
[PDF][PDF] Role of DNA mismatch repair defects in the pathogenesis of human cancer
P Peltomaki - Journal of clinical oncology, 2003 - academia.edu
The DNA mismatch repair (MMR) system is nec-essary for the maintenance of genomic
stability. In a broad sense, all main functions of the MMR system, including the correction of …
stability. In a broad sense, all main functions of the MMR system, including the correction of …
Molecular classification and correlates in colorectal cancer
Molecular classification of colorectal cancer is evolving. As our understanding of colorectal
carcinogenesis improves, we are incorporating new knowledge into the classification …
carcinogenesis improves, we are incorporating new knowledge into the classification …
Clinicopathological and molecular features of sessile serrated adenomas with dysplasia or carcinoma
Objective Sessile serrated adenomas (SSAs) are the precursors of at least 15% of colorectal
carcinomas, but their biology is incompletely understood. We performed a …
carcinomas, but their biology is incompletely understood. We performed a …
Carcinogenesis and microsatellite instability: the interrelationship between genetics and epigenetics
K Imai, H Yamamoto - Carcinogenesis, 2008 - academic.oup.com
DNA mismatch repair (MMR) deficiency results in a strong mutator phenotype and high-
frequency microsatellite instability (MSI-H), which are the hallmarks of tumors arising within …
frequency microsatellite instability (MSI-H), which are the hallmarks of tumors arising within …