Colorectal cancer (CRC) has traditionally been classified into two groups: microsatellite
stable/low-level instability (MSS/MSI-L) and high-level MSI (MSI-H) groups on the basis of …

Molecular pathological epidemiology (MPE) is an integrative molecular and population
health science that addresses the molecular pathogenesis and heterogeneity of disease …

Hyperplastic polyps have traditionally been considered not to have malignant potential. New
pathological classification of serrated polyps and recent discoveries about the serrated …

Molecular advances support the existence of an alternative pathway of colorectal
carcinogenesis that is based on the hypermethylation of specific DNA regions that silences …

BACKGROUND: Down-regulation of DNA repair genes has been proposed as an important
mechanism of tumorigenesis in some colon cancers. This mechanism has also recently …

Frequent microsatellite instability MSI (MSI-H) occurring in human tumors is characterized by
defective DNA mismatch repair and unique clinical features. However, infrequent MSI (MSI …

The influence of microsatellite instability (MSI) on the prognosis of colorectal cancer (CRC)
requires more investigation. We assessed the role of MSI status in survival of individuals …

In the past two decades, besides conventional adenoma pathway, a subset of colonic
lesions, including hyperplastic polyps, sessile serrated adenoma/polyps, and traditional …

Serrated polyps (SPs) of the colorectum pose a novel challenge to practicing
gastroenterologists. Previously thought benign and unimportant, there is now compelling …

Hyperplastic polyps have traditionally been regarded as nonneoplastic polyps lacking
malignant potential. The demonstration of genetic alterations within these lesions indicates …