The daily alternation between sleep and wakefulness is one of the most dominant features
of our lives and is a manifestation of the intrinsic 24 h rhythmicity underlying almost every …

Neurodegenerative diseases encompass a large group of conditions that are clinically and
pathologically diverse yet are linked by a shared pathology of misfolded proteins. The …

Disruptions of sleep and circadian rhythms are among the most debilitating symptoms in
patients with neurodegenerative diseases. Their underlying pathophysiology is multilayered …

Circadian rhythm disruption (CRD) is a shared characteristic of various brain disorders, such
as Alzheimer's disease (AD), Parkinson's disease (PD), and major depression disorder …

Autism spectrum disorders (ASDs) are a spectrum of neurodevelopmental disorders
characterized by impaired social interaction and communication, as well as stereotyped and …

Epigenetic clocks were initially developed to track chronological age, but accumulating
evidence indicates that they can also predict biological age. They are usually based on the …

Alzheimer's disease (AD) patients exhibit progressive disruption of entrained circadian
rhythms and an aberrant circadian input pathway may underlie such dysfunction. Here we …

The microbes that colonize the small and large intestines, known as the gut microbiome,
play an integral role in optimal brain development and function. The gut microbiome is a vital …

Aims The circadian clock is an internal biological timer that co-ordinates physiology and
gene expression with the 24-h solar day. Circadian clock perturbations have been …

Symptomatic interventions for patients with dementia involve anti-dementia drugs to improve
cognition, psychotropic drugs for the treatment of behavioral disorders (BDs), and different …