The plasminogen activation system is part of the fibrinolysis which is tightly regulated and
protected against dysfunction by various activators and inhibitors. However, microorganisms …

Among the seventeen species of the Gram-negative genus Yersinia, three have been shown
to be virulent and pathogenic to humans and animals—Y. enterocolitica, Y …

The interaction of plasminogen with cell surfaces results in promotion of plasmin formation
and retention on the cell surface. This results in arming cell surfaces with the broad …

The plasminogen activation system plays an integral role in the migration of macrophages in
response to an inflammatory stimulus, and the binding of plasminogen to its cell-surface …

The serine protease plasmin is distributed throughout the human body in the form of the
zymogen plasminogen. The plasminogen activation system is mostly recognized for its …

Activation of plasminogen, the zymogen of the primary thrombolytic enzyme, plasmin, is
markedly promoted when plasminogen is bound to cell surfaces, arming cells with the broad …

Endothelial cells form the inner lining of vascular networks and maintain blood fluidity by
inhibiting blood coagulation and promoting blood clot dissolution (fibrinolysis). Plasmin, the …

Abstract Lipoprotein (a)(Lp [a]) continues to be a controversial molecule regarding its role in
human vascular disease. Although the physiologic role of this molecule is still unclear, novel …

Plasminogen (Plg) facilitates inflammatory cell recruitment, a function that depends upon its
binding to Plg receptors (Plg-Rs). However, the Plg-Rs that are critical for cell migration are …

Localization of plasmin on macrophages and activation of pro–MMP-9 play key roles in
macrophage recruitment in the inflammatory response. These functions are promoted by …