Onchocerciasis (river blindness)–more than a century of research and control

NW Brattig, RA Cheke, R Garms - Acta Tropica, 2021 - Elsevier
This review summarises more than a century of research on onchocerciasis, also known as
river blindness, and its control. River blindness is an infection caused by the tissue filaria …

[HTML][HTML] In-silico design of a multi-epitope vaccine candidate against onchocerciasis and related filarial diseases

RA Shey, SM Ghogomu, KK Esoh, ND Nebangwa… - Scientific reports, 2019 - nature.com
Onchocerciasis is a parasitic disease with high socio-economic burden particularly in sub-
Saharan Africa. The elimination plan for this disease has faced numerous challenges. A …

Reaching the last mile: main challenges relating to and recommendations to accelerate onchocerciasis elimination in Africa

G Gebrezgabiher, Z Mekonnen… - Infectious diseases of …, 2019 - mednexus.org
Background: Onchocerciasis (river blindness), caused by the filarial worm species
Onchocerca volvulus, is a serious vector-borne neglected tropical disease (NTD) of public …

[HTML][HTML] Genomic epidemiology in filarial nematodes: transforming the basis for elimination program decisions

SM Hedtke, AC Kuesel, KE Crawford, PM Graves… - Frontiers in …, 2020 - frontiersin.org
Onchocerciasis and lymphatic filariasis are targeted for elimination, primarily using mass
drug administration at the country and community levels. Elimination of transmission is the …

[HTML][HTML] Genome-based tools for onchocerciasis elimination: Utility of the mitochondrial genome for delineating Onchocerca volvulus transmission zones

KE Crawford, SM Hedtke, SR Doyle, AC Kuesel… - International Journal for …, 2024 - Elsevier
National programs in Africa have expanded their objectives from control of onchocerciasis
(river blindness) as a public health problem to elimination of parasite transmission …

[HTML][HTML] Impact of annual versus semiannual mass drug administration with ivermectin and albendazole on helminth infections in southeastern Liberia

OA Eneanya, L Gankpala, CW Goss… - The American journal …, 2022 - ncbi.nlm.nih.gov
We compared the impact of three rounds of annual and five rounds of semiannual mass
drug administration (MDA) with albendazole plus ivermectin on helminthic infections in …

Integrating Multiple Biomarkers to Increase Sensitivity for the Detection of Onchocerca volvulus Infection

S Bennuru, G Oduro-Boateng, C Osigwe… - The Journal of …, 2020 - academic.oup.com
Background Serological assessments for human onchocerciasis are based on IgG4
reactivity against the OV-16 antigen, with sensitivities of 60-80%. We have previously …

[HTML][HTML] Onchocerciasis control in Ghana (1974–2016)

NK Biritwum, DK de Souza, O Asiedu, B Marfo… - Parasites & vectors, 2021 - Springer
Background The control of onchocerciasis in Ghana started in 1974 under the auspices of
the Onchocerciasis Control Programme (OCP). Between 1974 and 2002, a combination of …

[HTML][HTML] Development and deployment of an improved Anopheles gambiae sl field surveillance by adaptive spatial sampling design

GM Monteiro, LS Djogbenou, MJ Donnelly… - Frontiers in Ecology …, 2024 - frontiersin.org
Introduction Accurate assessments of vector occurrence and abundance, particularly in
widespread vector-borne diseases such as malaria, are crucial for the efficient deployment …

Impact of human movement between hypo- and hyperendemic areas on sustainability of elimination of Onchocerca volvulus transmission

K McCulloch, SM Hedtke, J McCaw, J McVernon… - medRxiv, 2023 - medrxiv.org
Background Onchocerciasis is a vector-borne disease caused by the filarial nematode
Onchocerca volvulus. Endemic countries target elimination of parasite transmission using …