The geroscience hypothesis proposes that addressing the biology of aging could directly
prevent the onset or mitigate the severity of multiple chronic diseases. Understanding the …

Aging is the subject of many studies, facilitating the discovery of many interventions.
Epigenetic influences numerous life processes by regulating gene expression and also …

Mammalian female reproductive lifespan is typically significantly shorter than life expectancy
and is associated with a decrease in ovarian NAD+ levels. However, the mechanisms …

Once considered a tissue culture-specific phenomenon, cellular senescence has now been
linked to various biological processes with both beneficial and detrimental roles in humans …

Pregnancy is a sensitive window period for bisphenol A (BPA) exposure. BPA can pass
through the placenta and cause reproductive damage in offspring female mice. Even BPA …

Sirt3 is a mitochondrial protein deacetylase functioning in energy metabolism, regulation of
intracellular reactive oxygen species (ROS) levels, and aging. Although Sirt3 loss has …

Ethnopharmacological relevance Marveled at the discovery of artemisinin, the world's
expectations for traditional Chinese medicine are rising. He's Yangchao formula (HSYC) is a …

Delaying childbearing age has become a trend in modern times, but it has also led to a
common challenge in clinical reproductive medicine—diminished ovarian reserve (DOR) …

Age-related aneuploidy in human oocytes is a major factor contributing to decreased fertility
and adverse reproductive outcomes. As females age, their oocytes are more prone to …

Heat stress induces testicular oxidative stress, impairs spermatogenesis, and increases the
risk of male infertility. Recent studies have highlighted the antioxidative properties of the …