The regulation of PBXs and their emerging role in cancer

Y Liu, X Ao, X Zhou, C Du… - Journal of Cellular and …, 2022 - Wiley Online Library
Pre‐B‐cell leukaemia transcription factor (PBX) proteins are a subfamily of evolutionarily
conserved, atypical homeodomain transcription factors that belong to the superfamily of …

New insights into mitophagy and stem cells

Q Lin, J Chen, L Gu, X Dan, C Zhang… - Stem cell research & …, 2021 - Springer
Mitophagy is a specific autophagic phenomenon in which damaged or redundant
mitochondria are selectively cleared by autophagic lysosomes. A decrease in mitophagy …

Low-dose BPA and its substitute BPS promote ovarian cancer cell stemness via a non-canonical PINK1/p53 mitophagic signaling

X Yuan, K Chen, F Zheng, S Xu, Y Li, Y Wang… - Journal of Hazardous …, 2023 - Elsevier
The environmental toxicity of bisphenol A (BPA) and its analog like bisphenol S (BPS) have
drawn wide attention, but their roles in cancer progression remain controversial. Here, we …

Co-targeting autophagy and NRF2 signaling triggers mitochondrial superoxide to sensitize oral cancer stem cells for cisplatin-induced apoptosis

PP Praharaj, A Singh, S Patra, SK Bhutia - Free Radical Biology and …, 2023 - Elsevier
Cancer stem cell (CSC) populations are regulated by autophagy, which in turn modulates
tumorigenicity and malignancy. In this study, we demonstrated that cisplatin treatment …

Mitochondrial dysfunction at the crossroad of cardiovascular diseases and cancer

C Rocca, T Soda, EM De Francesco, M Fiorillo… - Journal of Translational …, 2023 - Springer
A large body of evidence indicates the existence of a complex pathophysiological
relationship between cardiovascular diseases and cancer. Mitochondria are crucial …

Targeting autophagy and lipid metabolism in cancer stem cells

B Chakravarti, JA Siddiqui, RA Sinha, S Raza - Biochemical pharmacology, 2023 - Elsevier
Cancer stem cells (CSCs) are a subset of cancer cells with self-renewal ability and tumor
initiating properties. Unlike the other non-stem cancer cells, CSCs resist traditional therapy …

CLU (clusterin) promotes mitophagic degradation of MSX2 through an AKT-DNM1L/Drp1 axis to maintain SOX2-mediated stemness in oral cancer stem cells

PP Praharaj, S Patra, SR Mishra, S Mukhopadhyay… - Autophagy, 2023 - Taylor & Francis
Mitophagy regulates cancer stem cell (CSC) populations affecting tumorigenicity and
malignancy in various cancer types. Here, we report that cisplatin treatment led to the …

The multifaceted roles of mitochondria at the crossroads of cell life and death in cancer

F Fontana, P Limonta - Free Radical Biology and Medicine, 2021 - Elsevier
Mitochondria are the cytoplasmic organelles mostly known as the “electric engine” of the
cells; however, they also play pivotal roles in different biological processes, such as cell …

The mitochondrial calcium signaling, regulation, and cellular functions: A novel target for therapeutic medicine in neurological disorders

S Bagheri‐Mohammadi, M Farjami… - Journal of Cellular …, 2023 - Wiley Online Library
Abstract Mitochondrial calcium (Ca2+) dynamics play critical roles in regulating vital
physiological conditions in the brain. Importantly, Mitochondria‐associated endoplasmic …

SIRT1 inhibits mitochondrial hyperfusion associated mito-bulb formation to sensitize oral cancer cells for apoptosis in a mtROS-dependent signalling pathway

S Patra, A Singh, PP Praharaj, NK Mohanta… - Cell Death & …, 2023 - nature.com
SIRT1 (NAD-dependent protein deacetylase sirtuin-1), a class III histone deacetylase acting
as a tumor suppressor gene, is downregulated in oral cancer cells. Non-apoptotic doses of …