CD40 is essential in enabling antigen-presenting cells to process and present antigen
effectively to T cells. We demonstrate here that when antibody against CD40 is used to treat …

Cells from the bone marrow can present peptides that are derived from tumors, transplants,
and self-tissues. Here we describe how dendritic cells (DCs) process phagocytosed cell …

Neutrophils are professional phagocytes that migrate early, in high number, to the infection
sites. Our study has analyzed how neutrophils cross-present antigens and influence CD8+ T …

Extracellular proteins are not generally presented on class I MHC molecules in vitro, yet
many studies show that a pathway exists in vivo for the presentation of extracellular material …

Since the seminal discovery of dendritic cells (DCs) by Steinman and Cohn in 1973, there
has been an ongoing debate to what extent macrophages and DCs are related and perform …

To monitor the health of cells, the immune system tasks antigen-presenting cells with
gathering antigens from other cells and bringing them to CD8 T cells in the form of peptides …

The specificity and power of the cellular arm of the im-mune system may provide new
therapeutic approaches to cancer. With the assumption that T cells might be able to …

The SARS-CoV-2 pandemic introduced the world to a new type of vaccine based on mRNA
encapsulated in lipid nanoparticles (LNPs). Instead of delivering antigenic proteins directly …

The mannose receptor (MR) has been implicated in the recognition and clearance of
microorganisms and serum glycoproteins. Its endocytic function has been studied …

We previously described a mechanism for the maintenance of peripheral self-tolerance. This
involves the cross-presentation of tissue-associated antigens by a bone marrow–derived …