There are five fibroblast growth factor receptors (FGFRs), namely, FGFR1–FGFR5. When
FGFR binds to its ligand, namely, fibroblast growth factor (FGF), it dimerizes and …

Proteogenomics refers to the integration of comprehensive genomic, transcriptomic, and
proteomic measurements from the same samples with the goal of fully understanding the …

Cells contain intracellular compartments, including membrane-bound organelles and the
nucleus, and are surrounded by a plasma membrane. Proteins are localised to one or more …

The mammalian cell is a complex entity, with membrane-bound and membrane-less
organelles playing vital roles in regulating cellular homeostasis. Organellar protein niches …

The fibroblast growth factor (FGF) pathway is a conserved signaling pathway required for
embryonic development. Activated FGF receptor 1 (FGFR1) drives multiple intracellular …

Neural progenitor cells (NPCs) are essential for in vitro drug screening and cell-based
therapies for brain-related disorders, necessitating well-defined and reproducible culture …

Functional selectivity refers to the activation of differential signalling and cellular outputs
downstream of the same membrane-bound receptor when activated by two or more different …

Frequently, subcellular-targeted drugs tend to accumulate in lysosomes after cellular
absorption, a process termed the lysosomal trap. This accumulation often interferes with the …

Heart disease remains a leading cause of death in North America and worldwide. Despite
advances in therapies, the chronic nature of cardiovascular diseases ultimately results in …

The Fibroblast growth factor (FGF) pathway is a conserved signaling pathway required for
embryonic development. Activated FGF receptor 1 (FGFR1) drives multiple intracellular …