Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications

CC Jiang, LS Lin, S Long, XY Ke, K Fukunaga… - Signal transduction and …, 2022 - nature.com
Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental disorder
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …

Autism spectrum disorder: neuropathology and animal models

M Varghese, N Keshav, S Jacot-Descombes… - Acta …, 2017 - Springer
Autism spectrum disorder (ASD) has a major impact on the development and social
integration of affected individuals and is the most heritable of psychiatric disorders. An …

The neuropathology of autism: A systematic review of post-mortem studies of autism and related disorders

R Fetit, RF Hillary, DJ Price, SM Lawrie - Neuroscience & Biobehavioral …, 2021 - Elsevier
Post-mortem studies allow for the direct investigation of brain tissue in those with autism and
related disorders. Several review articles have focused on aspects of post-mortem …

The neuroanatomy of autism–a developmental perspective

APA Donovan, MA Basson - Journal of anatomy, 2017 - Wiley Online Library
Abstract Autism Spectrum Disorders (ASD s) are a heterogeneous group of
neurodevelopmental disorders that are diagnosed solely on the basis of behaviour. A large …

Cortical thickness abnormalities in autism spectrum disorders through late childhood, adolescence, and adulthood: a large-scale MRI study

BS Khundrakpam, JD Lewis, P Kostopoulos… - Cerebral …, 2017 - academic.oup.com
Neuroimaging studies in autism spectrum disorders (ASDs) have provided inconsistent
evidence of cortical abnormality. This is probably due to the small sample sizes used in most …

Development and developmental disorders of the human cerebellum

HJ ten Donkelaar, WFA den Dunnen… - … disorders of the human …, 2023 - Springer
The cerebellum is one of the best studied parts of the brain. The cerebellar cortex is
composed of four main types of neurons: granule cells, Purkinje cells, and two types of …

Stereological study of the neuronal number and volume of 38 brain subdivisions of subjects diagnosed with autism reveals significant alterations restricted to the …

J Wegiel, M Flory, I Kuchna, K Nowicki, SY Ma… - Acta neuropathologica …, 2014 - Springer
Introduction A total of 38 brain cytoarchitectonic subdivisions, representing subcortical and
cortical structures, cerebellum, and brainstem, were examined in 4-to 60-year-old subjects …

Early or late gestational exposure to maternal immune activation alters neurodevelopmental trajectories in mice: an integrated neuroimaging, behavioral, and …

E Guma, P do Couto Bordignon, GA Devenyi… - Biological …, 2021 - Elsevier
Background Exposure to maternal immune activation (MIA) in utero is a risk factor for
neurodevelopmental disorders later in life. The impact of the gestational timing of MIA …

Mitochondrial dysfunction in Autism Spectrum Disorder: clinical features and perspectives

F Hollis, AK Kanellopoulos, C Bagni - Current opinion in neurobiology, 2017 - Elsevier
Highlights•Numerous clinical studies highlight mitochondrial involvement in ASD.•Brain
mitochondrial function needs attention at the synaptic level.•Functional studies needed to …

Central auditory and vestibular dysfunction are key features of autism spectrum disorder

Y Mansour, A Burchell, RJ Kulesza - Frontiers in integrative …, 2021 - frontiersin.org
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by
repetitive behaviors, poor social skills, and difficulties with communication. Beyond these …